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Research Article

Analysis of the Gut Microbiota in the Old Order Amish and Its Relation to the Metabolic Syndrome

  • Margaret L. Zupancic equal contributor,

    equal contributor Contributed equally to this work with: Margaret L. Zupancic, Brandi L. Cantarel

    Affiliation: Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Brandi L. Cantarel equal contributor,

    equal contributor Contributed equally to this work with: Margaret L. Zupancic, Brandi L. Cantarel

    Affiliations: Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Zhenqiu Liu,

    Affiliation: Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Elliott F. Drabek,

    Affiliation: Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Kathleen A. Ryan,

    Affiliation: Program in Personalized and Genomic Medicine, Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Shana Cirimotich,

    Affiliation: Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Cheron Jones,

    Affiliation: Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Rob Knight,

    Affiliation: Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, Colorado, United States of America

    X
  • William A. Walters,

    Affiliation: Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, United States of America

    X
  • Daniel Knights,

    Affiliation: Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, Colorado, United States of America

    X
  • Emmanuel F. Mongodin,

    Affiliations: Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Richard B. Horenstein,

    Affiliation: Program in Personalized and Genomic Medicine, Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Braxton D. Mitchell,

    Affiliation: Program in Personalized and Genomic Medicine, Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Nanette Steinle,

    Affiliations: Program in Personalized and Genomic Medicine, Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, United States of America

    X
  • Soren Snitker,

    Affiliation: Program in Personalized and Genomic Medicine, Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Alan R. Shuldiner,

    Affiliations: Program in Personalized and Genomic Medicine, Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Veterans Administration Medical Center, Baltimore, Maryland, United States of America

    X
  • Claire M. Fraser mail

    cmfraser@som.umaryland.edu

    Affiliations: Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

    X
  • Published: August 15, 2012
  • DOI: 10.1371/journal.pone.0043052
  • Published in PLOS ONE

About the Authors

Margaret L. Zupancic, Brandi L. Cantarel, Elliott F. Drabek, Shana Cirimotich, Cheron Jones, Emmanuel F. Mongodin, Claire M. Fraser
Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
Claire M. Fraser
Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
Brandi L. Cantarel, Emmanuel F. Mongodin
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
Zhenqiu Liu
Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
Kathleen A. Ryan, Richard B. Horenstein, Braxton D. Mitchell, Nanette Steinle, Soren Snitker, Alan R. Shuldiner
Program in Personalized and Genomic Medicine, Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
Rob Knight, Daniel Knights
Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, Colorado, United States of America
William A. Walters, Nanette Steinle
Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, United States of America
Alan R. Shuldiner
Veterans Administration Medical Center, Baltimore, Maryland, United States of America

Corresponding Author

Email: cmfraser@som.umaryland.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CMF ARS NS RH SS. Performed the experiments: KAR SC CJ EM MLZ. Analyzed the data: BLC ZL EFD RK WAW BM DK. Wrote the paper: CMF ARS BLC EFD.