Table of Contents: Synthetic Biology Collection: Gene Network Engineering


Image Credit: Ivan Morozov (Virginia Bioinformatics Institute) / PLOS
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Synthetic Biology is an emerging, trans-disciplinary field at the intersection between many engineering and scientific disciplines such as biology, chemical engineering, chemistry, electrical engineering, and computer science.

This section of the Synthetic Biology Collection details papers related to Gene Network Engineering.

Articles in the Synthetic Biology Collection are presented in order of publication date and new articles will be added as they are published. PLOS welcome submissions in this field.

PLOS Collections:

Research Articles

Loads Bias Genetic and Signaling Switches in Synthetic and Natural Systems

Samanthe M. Lyons, Wenlong Xu, June Medford, Ashok Prasad

Modular Composition of Gene Transcription Networks

Andras Gyorgy, Domitilla Del Vecchio

Biological Signal Processing with a Genetic Toggle Switch

Patrick Hillenbrand, Georg Fritz, Ulrich Gerland

Multicellular Computing Using Conjugation for Wiring

Angel Goñi-Moreno, Martyn Amos, Fernando de la Cruz

A Formalized Design Process for Bacterial Consortia That Perform Logic Computing

Weiyue Ji, Handuo Shi, Haoqian Zhang, Rui Sun, Jingyi Xi, Dingqiao Wen, Jingchen Feng, Yiwei Chen, Xiao Qin, Yanrong Ma, Wenhan Luo, Linna Deng, Hanchi Lin, Ruofan Yu, Qi Ouyang

Synthetic miRNA-Mowers Targeting miR-183-96-182 Cluster or miR-210 Inhibit Growth and Migration and Induce Apoptosis in Bladder Cancer Cells

Yuchen Liu, Yonghua Han, Hu Zhang, Liping Nie, Zhimao Jiang, Pingping Fa, Yaoting Gui, Zhiming Cai

Programmable In Vivo Selection of Arbitrary DNA Sequences

Tuval Ben Yehezkel, Tamir Biezuner, Gregory Linshiz, Yair Mazor, Ehud Shapiro

Mapping the Environmental Fitness Landscape of a Synthetic Gene Circuit

Dmitry Nevozhay, Rhys M. Adams, Elizabeth Van Itallie, Matthew R. Bennett, Gábor Balázsi

A Feedback Quenched Oscillator Produces Turing Patterning with One Diffuser

Justin Hsia, William J. Holtz, Daniel C. Huang, Murat Arcak, Michel M. Maharbiz

Stochastic Delay Accelerates Signaling in Gene Networks

Krešimir Josić, José Manuel López, William Ott, LieJune Shiau, Matthew R. Bennett

Construction and Modelling of an Inducible Positive Feedback Loop Stably Integrated in a Mammalian Cell-Line

Velia Siciliano, Filippo Menolascina, Lucia Marucci, Chiara Fracassi, Immacolata Garzilli, Maria Nicoletta Moretti, Diego di Bernardo

A Multi-Functional Synthetic Gene Network: A Frequency Multiplier, Oscillator and Switch

Oliver Purcell, Mario di Bernardo, Claire S. Grierson, Nigel J. Savery

Programmable Ligand Detection System in Plants through a Synthetic Signal Transduction Pathway

Mauricio S. Antunes, Kevin J. Morey, J. Jeff Smith, Kirk D. Albrecht, Tessa A. Bowen, Jeffrey K. Zdunek, Jared F. Troupe, Matthew J. Cuneo, Colleen T. Webb, Homme W. Hellinga, June I. Medford

Oscillations by Minimal Bacterial Suicide Circuits Reveal Hidden Facets of Host-Circuit Physiology

Philippe Marguet, Yu Tanouchi, Eric Spitz, Cameron Smith, Lingchong You

An Environment-Sensitive Synthetic Microbial Ecosystem

Bo Hu, Jin Du, Rui-yang Zou, Ying-jin Yuan

How to Turn a Genetic Circuit into a Synthetic Tunable Oscillator, or a Bistable Switch

Lucia Marucci, David A. W. Barton, Irene Cantone, Maria Aurelia Ricci, Maria Pia Cosma, Stefania Santini, Diego di Bernardo, Mario di Bernardo

Monomeric Bistability and the Role of Autoloops in Gene Regulation

Stefanie Widder, Javier Macía, Ricard Solé

Timing Cellular Decision Making Under Noise via Cell–Cell Communication

Aneta Koseska, Alexey Zaikin, Jürgen Kurths, Jordi García-Ojalvo

Bimodal and Hysteretic Expression in Mammalian Cells from a Synthetic Gene Circuit

Tobias May, Lee Eccleston, Sabrina Herrmann, Hansjörg Hauser, Jorge Goncalves, Dagmar Wirth

Reconstitution of Mdm2-Dependent Post-Translational Modifications of p53 in Yeast

Barbara Di Ventura, Charlotta Funaya, Claude Antony, Michael Knop, Luis Serrano