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Table of Contents: The Global Challenges of Noncommunicable Diseases


The Global Challenges of Noncommunicable Diseases

Image Credit: No Smoking (Top Left): Satish Krishnamurthy, Flickr; Body Scale (Top Right): Daniel Oines, Flickr; Finger Test (Bottom Left): Biswarup Ganguly, Wikimedia Commons; Gauge (Bottom Right): Bernard Goldbach, Flickr
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Noncommunicable diseases (NCDs) are responsible for two-thirds of the world's deaths, one-fourth of which occur before the age of 60. Nearly 80% of NCD deaths occur in low- and middle-income countries, where they are also increasing most rapidly. With these global needs and disparities in mind, the editors of PLOS Medicine issued a call for papers into research and commentary on NCDs directed toward improving population health and reducing health disparities. For this theme, we include as part of the definition of NCD research the identification, treatment, and prevention of mental health and substance use disorders, as both cause considerable morbidity and mortality, contribute to NCDs, and similarly require the health systems necessary to care for chronic conditions.

This Collection brings together research and commentary published in PLOS Medicine over 2013 that examines the global challenges and opportunities for addressing noncommunicable disease around the world.

The Collection will be updated periodically with new research and commentary on NCDs published in PLOS Medicine.

Collection Citation: The Global Challenges of Noncommunicable Diseases (2013)

PLOS Collections: www.ploscollections.org/noncommunicablediseases




Health in Action

Policy Forums

Recent Shifts in Global Governance: Implications for the Response to Non-communicable Diseases

Devi Sridhar, Claire E. Brolan, Shireen Durrani, Jennifer Edge, Lawrence O. Gostin, Peter Hill, Martin McKee

Research Articles

Erectile Dysfunction Severity as a Risk Marker for Cardiovascular Disease Hospitalisation and All-Cause Mortality: A Prospective Cohort Study

Emily Banks, Grace Joshy, Walter P. Abhayaratna, Leonard Kritharides, Peter S. Macdonald, Rosemary J. Korda, John P. Chalmers

Socioeconomic Inequalities in Lung Cancer Treatment: Systematic Review and Meta-Analysis

Lynne F. Forrest, Jean Adams, Helen Wareham, Greg Rubin, Martin White

Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts

Karani S. Vimaleswaran, Diane J. Berry, Chen Lu, Emmi Tikkanen, Stefan Pilz, Linda T. Hiraki, Jason D. Cooper, Zari Dastani, Rui Li, Denise K. Houston, Andrew R. Wood, Karl Michaëlsson, Liesbeth Vandenput, Lina Zgaga, Laura M. Yerges-Armstrong, Mark I. McCarthy, Josée Dupuis, Marika Kaakinen, Marcus E. Kleber, Karen Jameson, Nigel Arden, Olli Raitakari, Jorma Viikari, Kurt K. Lohman, Luigi Ferrucci, Håkan Melhus, Erik Ingelsson, Liisa Byberg, Lars Lind, Mattias Lorentzon, Veikko Salomaa, Harry Campbell, Malcolm Dunlop, Braxton D. Mitchell, Karl-Heinz Herzig, Anneli Pouta, Anna-Liisa Hartikainen, Elizabeth A. Streeten, Evropi Theodoratou, Antti Jula, Nicholas J. Wareham, Claes Ohlsson, Timothy M. Frayling, Stephen B. Kritchevsky, Timothy D. Spector, J. Brent Richards, Terho Lehtimäki, Willem H. Ouwehand, Peter Kraft, Cyrus Cooper, Winfried März, Chris Power, Ruth J. F. Loos, Thomas J. Wang, Marjo-Riitta Järvelin, John C. Whittaker, Aroon D. Hingorani, Elina Hyppönen , the Genetic Investigation of Anthropometric Traits (GIANT) consortium

Adjunctive Atypical Antipsychotic Treatment for Major Depressive Disorder: A Meta-Analysis of Depression, Quality of Life, and Safety Outcomes

Glen I. Spielmans, Margit I. Berman, Eftihia Linardatos, Nicholas Z. Rosenlicht, Angela Perry, Alexander C. Tsai

Changing Patterns in Place of Cancer Death in England: A Population-Based Study

Wei Gao, Yuen K. Ho, Julia Verne, Myer Glickman, Irene J. Higginson , on behalf of the GUIDE_Care project

Preeclampsia as a Risk Factor for Diabetes: A Population-Based Cohort Study

Denice S. Feig, Baiju R. Shah, Lorraine L. Lipscombe, C. Fangyun Wu, Joel G. Ray, Julia Lowe, Jeremiah Hwee, Gillian L. Booth

Fine Particulate Air Pollution and the Progression of Carotid Intima-Medial Thickness: A Prospective Cohort Study from the Multi-Ethnic Study of Atherosclerosis and Air Pollution

Sara D. Adar, Lianne Sheppard, Sverre Vedal, Joseph F. Polak, Paul D. Sampson, Ana V. Diez Roux, Matthew Budoff, David R. Jacobs Jr, R. Graham Barr, Karol Watson, Joel D. Kaufman

Risk of a Second Primary Cancer after Non-melanoma Skin Cancer in White Men and Women: A Prospective Cohort Study

Fengju Song, Abrar A. Qureshi, Edward L. Giovannucci, Charlie S. Fuchs, Wendy Y. Chen, Meir J. Stampfer, Jiali Han

Intimate Partner Violence and Incident Depressive Symptoms and Suicide Attempts: A Systematic Review of Longitudinal Studies

Karen M. Devries, Joelle Y. Mak, Loraine J. Bacchus, Jennifer C. Child, Gail Falder, Max Petzold, Jill Astbury, Charlotte H. Watts

Contribution of H. pylori and Smoking Trends to US Incidence of Intestinal-Type Noncardia Gastric Adenocarcinoma: A Microsimulation Model

Jennifer M. Yeh, Chin Hur, Deb Schrag, Karen M. Kuntz, Majid Ezzati, Natasha Stout, Zachary Ward, Sue J. Goldie

Domestic Violence and Perinatal Mental Disorders: A Systematic Review and Meta-Analysis

Louise M. Howard, Sian Oram, Helen Galley, Kylee Trevillion, Gene Feder

Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic Value

Laetitia Marisa, Aurélien de Reyniès, Alex Duval, Janick Selves, Marie Pierre Gaub, Laure Vescovo, Marie-Christine Etienne-Grimaldi, Renaud Schiappa, Dominique Guenot, Mira Ayadi, Sylvain Kirzin, Maurice Chazal, Jean-François Fléjou, Daniel Benchimol, Anne Berger, Arnaud Lagarde, Erwan Pencreach, Françoise Piard, Dominique Elias, Yann Parc, Sylviane Olschwang, Gérard Milano, Pierre Laurent-Puig, Valérie Boige

Comparative Efficacy of Seven Psychotherapeutic Interventions for Patients with Depression: A Network Meta-Analysis

Jürgen Barth, Thomas Munder, Heike Gerger, Eveline Nüesch, Sven Trelle, Hansjörg Znoj, Peter Jüni, Pim Cuijpers

Associations between Active Travel to Work and Overweight, Hypertension, and Diabetes in India: A Cross-Sectional Study

Christopher Millett, Sutapa Agrawal, Ruth Sullivan, Mario Vaz, Anura Kurpad, A. V. Bharathi, Dorairaj Prabhakaran, Kolli Srinath Reddy, Sanjay Kinra, George Davey Smith, Shah Ebrahim , for the Indian Migration Study group

Diet and Physical Activity for the Prevention of Noncommunicable Diseases in Low- and Middle-Income Countries: A Systematic Policy Review

Carl Lachat, Stephen Otchere, Dominique Roberfroid, Abubakari Abdulai, Florencia Maria Aguirre Seret, Jelena Milesevic, Godfrey Xuereb, Vanessa Candeias, Patrick Kolsteren

Uncovering Treatment Burden as a Key Concept for Stroke Care: A Systematic Review of Qualitative Research

Katie Gallacher, Deborah Morrison, Bhautesh Jani, Sara Macdonald, Carl R. May, Victor M. Montori, Patricia J. Erwin, G. David Batty, David T. Eton, Peter Langhorne, Frances S. Mair

The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis

Tove Fall, Sara Hägg, Reedik Mägi, Alexander Ploner, Krista Fischer, Momoko Horikoshi, Antti-Pekka Sarin, Gudmar Thorleifsson, Claes Ladenvall, Mart Kals, Maris Kuningas, Harmen H. M. Draisma, Janina S. Ried, Natalie R. van Zuydam, Ville Huikari, Massimo Mangino, Emily Sonestedt, Beben Benyamin, Christopher P. Nelson, Natalia V. Rivera, Kati Kristiansson, Huei-yi Shen, Aki S. Havulinna, Abbas Dehghan, Louise A. Donnelly, Marika Kaakinen, Marja-Liisa Nuotio, Neil Robertson, Renée F. A. G. de Bruijn, M. Arfan Ikram, Najaf Amin, Anthony J. Balmforth, Peter S. Braund, Alexander S. F. Doney, Angela Döring, Paul Elliott, Tõnu Esko, Oscar H. Franco, Solveig Gretarsdottir, Anna-Liisa Hartikainen, Kauko Heikkilä, Karl-Heinz Herzig, Hilma Holm, Jouke Jan Hottenga, Elina Hyppönen, Thomas Illig, Aaron Isaacs, Bo Isomaa, Lennart C. Karssen, Johannes Kettunen, Wolfgang Koenig, Kari Kuulasmaa, Tiina Laatikainen, Jaana Laitinen, Cecilia Lindgren, Valeriya Lyssenko, Esa Läärä, Nigel W. Rayner, Satu Männistö, Anneli Pouta, Wolfgang Rathmann, Fernando Rivadeneira, Aimo Ruokonen, Markku J. Savolainen, Eric J. G. Sijbrands, Kerrin S. Small, Jan H. Smit, Valgerdur Steinthorsdottir, Ann-Christine Syvänen, Anja Taanila, Martin D. Tobin, Andre G. Uitterlinden, Sara M. Willems, Gonneke Willemsen, Jacqueline Witteman, Markus Perola, Alun Evans, Jean Ferrières, Jarmo Virtamo, Frank Kee, David-Alexandre Tregouet, Dominique Arveiler, Philippe Amouyel, Marco M. Ferrario, Paolo Brambilla, Alistair S. Hall, Andrew C. Heath, Pamela A. F. Madden, Nicholas G. Martin, Grant W. Montgomery, John B. Whitfield, Antti Jula, Paul Knekt, Ben Oostra, Cornelia M. van Duijn, Brenda W. J. H. Penninx, George Davey Smith, Jaakko Kaprio, Nilesh J. Samani, Christian Gieger, Annette Peters, H.-Erich Wichmann, Dorret I. Boomsma, Eco J. C. de Geus, TiinaMaija Tuomi, Chris Power, Christopher J. Hammond, Tim D. Spector, Lars Lind, Marju Orho-Melander, Colin Neil Alexander Palmer, Andrew D. Morris, Leif Groop, Marjo-Riitta Järvelin, Veikko Salomaa, Erkki Vartiainen, Albert Hofman, Samuli Ripatti, Andres Metspalu, Unnur Thorsteinsdottir, Kari Stefansson, Nancy L. Pedersen, Mark I. McCarthy, Erik Ingelsson, Inga Prokopenko , for the European Network for Genetic and Genomic Epidemiology (ENGAGE) consortium

Association of Lifecourse Socioeconomic Status with Chronic Inflammation and Type 2 Diabetes Risk: The Whitehall II Prospective Cohort Study

Silvia Stringhini, G. David Batty, Pascal Bovet, Martin J. Shipley, Michael G. Marmot, Meena Kumari, Adam G. Tabak, Mika Kivimäki

The Influence of Health Systems on Hypertension Awareness, Treatment, and Control: A Systematic Literature Review

Will Maimaris, Jared Paty, Pablo Perel, Helena Legido-Quigley, Dina Balabanova, Robby Nieuwlaat, Martin Mckee

Risk Prediction for Breast, Endometrial, and Ovarian Cancer in White Women Aged 50 y or Older: Derivation and Validation from Population-Based Cohort Studies

Ruth M. Pfeiffer, Yikyung Park, Aimée R. Kreimer, James V. Lacey Jr, David Pee, Robert T. Greenlee, Saundra S. Buys, Albert Hollenbeck, Bernard Rosner, Mitchell H. Gail, Patricia Hartge

Inclusion of Ethical Issues in Dementia Guidelines: A Thematic Text Analysis

Hannes Knüppel, Marcel Mertz, Martina Schmidhuber, Gerald Neitzke, Daniel Strech

Acupuncture and Counselling for Depression in Primary Care: A Randomised Controlled Trial

Hugh MacPherson, Stewart Richmond, Martin Bland, Stephen Brealey, Rhian Gabe, Ann Hopton, Ada Keding, Harriet Lansdown, Sara Perren, Mark Sculpher, Eldon Spackman, David Torgerson, Ian Watt

Burden of Depressive Disorders by Country, Sex, Age, and Year: Findings from the Global Burden of Disease Study 2010

Alize J. Ferrari, Fiona J. Charlson, Rosana E. Norman, Scott B. Patten, Greg Freedman, Christopher J.L. Murray, Theo Vos, Harvey A. Whiteford

Averting Obesity and Type 2 Diabetes in India through Sugar-Sweetened Beverage Taxation: An Economic-Epidemiologic Modeling Study

Sanjay Basu, Sukumar Vellakkal, Sutapa Agrawal, David Stuckler, Barry Popkin, Shah Ebrahim

Muscle-Strengthening and Conditioning Activities and Risk of Type 2 Diabetes: A Prospective Study in Two Cohorts of US Women

Anders Grøntved, An Pan, Rania A. Mekary, Meir Stampfer, Walter C. Willett, JoAnn E. Manson, Frank B. Hu

Long-Term Survival and Dialysis Dependency Following Acute Kidney Injury in Intensive Care: Extended Follow-up of a Randomized Controlled Trial

Martin Gallagher, Alan Cass, Rinaldo Bellomo, Simon Finfer, David Gattas, Joanne Lee, Serigne Lo, Shay McGuinness, John Myburgh, Rachael Parke, Dorrilyn Rajbhandari , for the POST-RENAL Study Investigators and the ANZICS Clinical Trials Group

Risk Stratification by Self-Measured Home Blood Pressure across Categories of Conventional Blood Pressure: A Participant-Level Meta-Analysis

Kei Asayama, Lutgarde Thijs, Jana Brguljan-Hitij, Teemu J. Niiranen, Atsushi Hozawa, José Boggia, Lucas S. Aparicio, Azusa Hara, Jouni K. Johansson, Takayoshi Ohkubo, Christophe Tzourio, George S. Stergiou, Edgardo Sandoya, Ichiro Tsuji, Antti M. Jula, Yutaka Imai, Jan A. Staessen , for the International Database of Home Blood Pressure in Relation to Cardiovascular Outcome (IDHOCO) investigators

Preterm Birth and Childhood Wheezing Disorders: A Systematic Review and Meta-Analysis

Jasper V. Been, Marlies J. Lugtenberg, Eline Smets, Constant P. van Schayck, Boris W. Kramer, Monique Mommers, Aziz Sheikh

A Risk Prediction Model for the Assessment and Triage of Women with Hypertensive Disorders of Pregnancy in Low-Resourced Settings: The miniPIERS (Pre-eclampsia Integrated Estimate of RiSk) Multi-country Prospective Cohort Study

Beth A. Payne, Jennifer A. Hutcheon, J. Mark Ansermino, David R. Hall, Zulfiqar A. Bhutta, Shereen Z. Bhutta, Christine Biryabarema, William A. Grobman, Henk Groen, Farizah Haniff, Jing Li, Laura A. Magee, Mario Merialdi, Annettee Nakimuli, Ziguang Qu, Rozina Sikandar, Nelson Sass, Diane Sawchuck, D. Wilhelm Steyn, Mariana Widmer, Jian Zhou, Peter von Dadelszen , for the miniPIERS Study Working Group

Effect of an Educational Toolkit on Quality of Care: A Pragmatic Cluster Randomized Trial

Baiju R. Shah, Onil Bhattacharyya, Catherine H. Y. Yu, Muhammad M. Mamdani, Janet A. Parsons, Sharon E. Straus, Merrick Zwarenstein

Obstructive Sleep Apnea and Risk of Cardiovascular Events and All-Cause Mortality: A Decade-Long Historical Cohort Study

Tetyana Kendzerska, Andrea S. Gershon, Gillian Hawker, Richard S. Leung, George Tomlinson

Patterns of Obesity Development before the Diagnosis of Type 2 Diabetes: The Whitehall II Cohort Study

Dorte Vistisen, Daniel R. Witte, Adam G. Tabák, Christian Herder, Eric J. Brunner, Mika Kivimäki, Kristine Færch