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Table of Contents: PLOS Neglected Tropical Diseases: Strongyloides Collection

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Image Credit: Maria Gobbo, Centre for Tropical Diseases Verona, Italy
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When global policymakers address the health and economic impact of the soil-transmitted helminth infections, they generally refer to the "unholy trinity" of ascariasis, hookworm infection, and trichuriasis. However, increasing information suggests that strongyloidiasis is an important fourth soil-transmitted helminthiasis. There are many reasons for the global neglect of strongyloidiasis, not the least of which is the inconvenient truth that there are little or no global burden of disease data for this infection, nor even any accurate accounting for the actual number of people infected. We also know very little about the true geographic distribution of strongyloidiasis. This special collection will help to highlight this somewhat mysterious yet very important neglected tropical disease, its enormous potential global impact on human health, and the urgent need for basic and applied research.

Filariform (L3) larvae of Strongyloides stercoralis obtained from a stool culture (see Bisoffi et al., 10.1371/journal.pntd.0002214).

Viewpoints

Strongyloides stercoralis: A Plea for Action

Zeno Bisoffi, Dora Buonfrate, Antonio Montresor, Ana Requena-Méndez, Jose Muñoz, Alejandro J. Krolewiecki, Eduardo Gotuzzo, Maria Alejandra Mena, Peter L. Chiodini, Mariella Anselmi, Juan Moreira, Marco Albonico

Review

A Public Health Response against Strongyloides stercoralis: Time to Look at Soil-Transmitted Helminthiasis in Full

Alejandro J. Krolewiecki, Patrick Lammie, Julie Jacobson, Albis-Francesco Gabrielli, Bruno Levecke, Eugenia Socias, Luis M. Arias, Nicanor Sosa, David Abraham, Ruben Cimino, Adriana Echazú, Favio Crudo, Jozef Vercruysse, Marco Albonico

Research Articles

Strongyloides stercoralis: Global Distribution and Risk Factors

Fabian Schär, Ulf Trostdorf, Federica Giardina, Virak Khieu, Sinuon Muth, Hanspeter Marti, Penelope Vounatsou, Peter Odermatt

Diagnosis, Treatment and Risk Factors of Strongyloides stercoralis in Schoolchildren in Cambodia

Virak Khieu, Fabian Schär, Hanspeter Marti, Somphou Sayasone, Socheat Duong, Sinuon Muth, Peter Odermatt

RNAseq Analysis of the Parasitic Nematode Strongyloides stercoralis Reveals Divergent Regulation of Canonical Dauer Pathways

Jonathan D. Stoltzfus, Samuel Minot, Matthew Berriman, Thomas J. Nolan, James B. Lok

The Transcriptome Analysis of Strongyloides stercoralis L3i Larvae Reveals Targets for Intervention in a Neglected Disease

Antonio Marcilla, Gagan Garg, Dolores Bernal, Shoba Ranganathan, Javier Forment, Javier Ortiz, Carla Muñoz-Antolí, M. Victoria Dominguez, Laia Pedrola, Juan Martinez-Blanch, Javier Sotillo, Maria Trelis, Rafael Toledo, J. Guillermo Esteban

Diagnosis, Clinical Features, and Self-Reported Morbidity of Strongyloides stercoralis and Hookworm Infection in a Co-Endemic Setting

Sören L. Becker, Benjamin Sieto, Kigbafori D. Silué, Lucas Adjossan, Siaka Koné, Christoph Hatz, Winfried V. Kern, Eliézer K. N'Goran, Jürg Utzinger

Microarray-Based Analysis of Differential Gene Expression between Infective and Noninfective Larvae of Strongyloides stercoralis

Roshan Ramanathan, Sudhir Varma, José M. C. Ribeiro, Timothy G. Myers, Thomas J. Nolan, David Abraham, James B. Lok, Thomas B. Nutman

Alcoholism and Strongyloides stercoralis: Daily Ethanol Ingestion Has a Positive Correlation with the Frequency of Strongyloides Larvae in the Stools

Carla Couzi Marques, Maria da Penha Zago-Gomes, Carlos Sandoval Gonçalves, Fausto Edmundo Lima Pereira

Regulatory T Cell Expansion in HTLV-1 and Strongyloidiasis Co-infection Is Associated with Reduced IL-5 Responses to Strongyloides stercoralis Antigen

Martin Montes, Cesar Sanchez, Kristien Verdonck, Jordan E. Lake, Elsa Gonzalez, Giovanni Lopez, Angelica Terashima, Thomas Nolan, Dorothy E. Lewis, Eduardo Gotuzzo, A. Clinton White Jr

Tribendimidine and Albendazole for Treating Soil-Transmitted Helminths, Strongyloides stercoralis and Taenia spp.: Open-Label Randomized Trial

Peter Steinmann, Xiao-Nong Zhou, Zun-Wei Du, Jin-Yong Jiang, Shu-Hua Xiao, Zhong-Xing Wu, Hui Zhou, Jürg Utzinger

Strongyloides ratti: In Vitro and In Vivo Activity of Tribendimidine

Jennifer Keiser, Kai Thiemann, Yvette Endriss, Jürg Utzinger

Occurrence of Strongyloides stercoralis in Yunnan Province, China, and Comparison of Diagnostic Methods

Peter Steinmann, Xiao-Nong Zhou, Zun-Wei Du, Jin-Yong Jiang, Li-Bo Wang, Xue-Zhong Wang, Lan-Hua Li, Hanspeter Marti, Jürg Utzinger