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Table of Contents: Advances in HIV Mucosal Immunology: Challenges and Opportunities

COVER

Image Credit: Artistic rendition of immune cells and potential HIV targets in the rectal mucosal. Yang, Ochoa, Preza & Anton, 2014
Issue Image

Without reliable methods to evaluate how the mucosal immune system responds to an experimental HIV vaccine, important information about how well that vaccine worked - and how to improve the next one - is missed.

The HIV Mucosal Immunology Group (MIG) was established to address the challenge of assessing the impact of potential HIV vaccines on the mucosal immune system. The MIG comprises a group of expert scientists who are coordinating their efforts to improve mucosal sampling, specimen storage and assay technologies, with emphasis on methods that gain maximum information from limited amounts of mucosal secretions, cells and tissues.

The Advances in Mucosal Immunology: Challenges and Opportunities Collection reports the results of the efforts of MIG investigators, providing important, practical details on studying immune responses in the genital and rectal mucosa, which will help guide future studies of HIV prevention with vaccines and topical microbicides.

The Collection image is an artistic rendition of Lymphocytes (orange), macrophages (purple), dendritic cells (green) and Langerhans-like cells (red) overlaid onto a confocal microscopic image from a sectioned rectal mucosal biopsy, using DAPI-staining of cell nuclei. The mucosal epithelial cells are represented by the string of blue nuclei at the top.

New papers will be added to this Collection on a regular basis.

Collection Citation: Advances in HIV Mucosal Immunology: Challenges and Opportunities (2014)

PLOS Collections: http://www.ploscollections.org/mucosalimmunology

Research Articles

Acceptability and Feasibility of Repeated Mucosal Specimen Collection in Clinical Trial Participants in Kenya

Gloria Omosa-Manyonyi, Harriet Park, Gaudensia Mutua, Bashir Farah, Philip J. Bergin, Dagna Laufer, Jennifer Lehrman, Kundai Chinyenze, Burc Barin, Pat Fast, Jill Gilmour, Omu Anzala

A Multi-Compartment Single and Multiple Dose Pharmacokinetic Comparison of Rectally Applied Tenofovir 1% Gel and Oral Tenofovir Disoproxil Fumarate

Kuo-Hsiung Yang, Craig Hendrix, Namandje Bumpus, Julie Elliott, Karen Tanner, Christine Mauck, Ross Cranston, Ian McGowan, Nicola Richardson-Harman, Peter A. Anton, Angela D. M. Kashuba

Correlation between Compartmental Tenofovir Concentrations and an Ex Vivo Rectal Biopsy Model of Tissue Infectibility in the RMP-02/MTN-006 Phase 1 Study

Nicola Richardson-Harman, Craig W. Hendrix, Namandjé N. Bumpus, Christine Mauck, Ross D. Cranston, Kuo Yang, Julie Elliott, Karen Tanner, Ian McGowan, Angela Kashuba, Peter A. Anton

The Inner Foreskin of Healthy Males at Risk of HIV Infection Harbors Epithelial CD4+ CCR5+ Cells and Has Features of an Inflamed Epidermal Barrier

Maria P. Lemos, Javier R. Lama, Shelly T. Karuna, Youyi Fong, Silvia M. Montano, Carmela Ganoza, Raphael Gottardo, Jorge Sanchez, M. Juliana McElrath

HIV-1 Specific IgA Detected in Vaginal Secretions of HIV Uninfected Women Participating in a Microbicide Trial in Southern Africa Are Primarily Directed Toward gp120 and gp140 Specificities

Kelly E. Seaton, Lamar Ballweber, Audrey Lan, Michele Donathan, Sean Hughes, Lucia Vojtech, M. Anthony Moody, Hua-Xin Liao, Barton F. Haynes, Christine G. Galloway, Barbra A. Richardson, Salim Abdool Karim, Charlene S. Dezzutti, M. Juliana McElrath, Georgia D. Tomaras, Florian Hladik

Development of HIV-1 Rectal-Specific Microbicides and Colonic Tissue Evaluation

Charlene S. Dezzutti, Julie Russo, Lin Wang, Kaleab Z. Abebe, Jie Li, David R. Friend, Ian M. McGowan, Lisa C. Rohan

A Comparative Proteomic Analysis of the Soluble Immune Factor Environment of Rectal and Oral Mucosa

Laura M. Romas, Klara Hasselrot, Lindsay G. Aboud, Kenzie D. Birse, T. Blake Ball, Kristina Broliden, Adam D. Burgener

Differential Blood and Mucosal Immune Responses against an HIV-1 Vaccine Administered via Inguinal or Deltoid Injection

Otto O. Yang, F. Javier Ibarrondo, Charles Price, Lance E. Hultin, Julie Elliott, Patricia M. Hultin, Roger Shih, Mary Ann Hausner, Hwee L. Ng, Jennifer Hoffman, Beth D. Jamieson, Peter A. Anton

Optimizing Viable Leukocyte Sampling from the Female Genital Tract for Clinical Trials: An International Multi-Site Study

Lyle R. McKinnon, Sean M. Hughes, Stephen C. De Rosa, Jeffrey A. Martinson, Jill Plants, Kirsten E. Brady, Pamela P. Gumbi, Devin J. Adams, Lucia Vojtech, Christine G. Galloway, Michael Fialkow, Gretchen Lentz, Dayong Gao, Zhiquan Shu, Billy Nyanga, Preston Izulla, Joshua Kimani, Steve Kimwaki, Alfred Bere, Zoe Moodie, Alan L. Landay, Jo-Ann S. Passmore, Rupert Kaul, Richard M. Novak, M. Juliana McElrath, Florian Hladik

Unbiased Proteomics Analysis Demonstrates Significant Variability in Mucosal Immune Factor Expression Depending on the Site and Method of Collection

Kenzie M. Birse, Adam Burgener, Garrett R. Westmacott, Stuart McCorrister, Richard M. Novak, T. Blake Ball

HIV-1 Nef Sequence and Functional Compartmentalization in the Gut Is Not Due to Differential Cytotoxic T Lymphocyte Selective Pressure

Martha J. Lewis, Patricia Frohnen, F. Javier Ibarrondo, Diane Reed, Varun Iyer, Hwee L. Ng, Julie Elliott, Otto O. Yang, Peter Anton