Without reliable methods to evaluate how the mucosal immune system responds to an experimental HIV vaccine, important information about how well that vaccine worked - and how to improve the next one - is missed.
The HIV Mucosal Immunology Group (MIG) was established to address the challenge of assessing the impact of potential HIV vaccines on the mucosal immune system. The MIG comprises a group of expert scientists who are coordinating their efforts to improve mucosal sampling, specimen storage and assay technologies, with emphasis on methods that gain maximum information from limited amounts of mucosal secretions, cells and tissues.
The Advances in Mucosal Immunology: Challenges and Opportunities Collection reports the results of the efforts of MIG investigators, providing important, practical details on studying immune responses in the genital and rectal mucosa, which will help guide future studies of HIV prevention with vaccines and topical microbicides.
The Collection image is an artistic rendition of Lymphocytes (orange), macrophages (purple), dendritic cells (green) and Langerhans-like cells (red) overlaid onto a confocal microscopic image from a sectioned rectal mucosal biopsy, using DAPI-staining of cell nuclei. The mucosal epithelial cells are represented by the string of blue nuclei at the top.
New papers will be added to this Collection on a regular basis.
Collection Citation: Advances in HIV Mucosal Immunology: Challenges and Opportunities (2014)
PLOS Collections: http://www.ploscollections.org/mucosalimmunology
PLOS ONE: published 18 Feb 2014 | info:doi/10.1371/journal.pone.0088621
PLOS ONE: published 15 Jan 2014 | info:doi/10.1371/journal.pone.0085675
PLOS ONE: published 14 Nov 2013 | info:doi/10.1371/journal.pone.0079505
PLOS ONE: published 13 Sep 2013 | info:doi/10.1371/journal.pone.0075620