Table of Contents: Structural Biology and Human Health: Medically Relevant Proteins from the SGC


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This collection of articles represents some of the research highlights from the SGC ( ). The SGC is an international public-private partnership that determines three dimensional structures of medically important proteins from both human and human parasites and places this information into the public domain, free from restrictions on use. The articles describe the structure and further characterisation of the proteins in an easily accessible way. All articles in this collection can be read on-line as interactive documents, where relevant features described in the text can be visualised as 3D molecular scenes that can be directly manipulated by the reader. New articles will be added to the collection as they are published.

Image Credit: Wen Hwa Lee of the SGC.


A New Method for Publishing Three-Dimensional Content

Eugene Raush, Max Totrov, Brian D. Marsden, Ruben Abagyan

SGC - Structural Biology and Human Health: A New Approach to Publishing Structural Biology Results

Wen Hwa Lee, Julián Atienza-Herrero, Ruben Abagyan, Brian D. Marsden


Research Articles

Crystal Structures of the Catalytic Domain of Human Soluble Guanylate Cyclase

Charles K. Allerston, Frank von Delft, Opher Gileadi

Characterization of 14-3-3 Proteins from Cryptosporidium parvum

Stephen J. Brokx, Amy K. Wernimont, Aiping Dong, Gregory A. Wasney, Yu-Hui Lin, Jocelyne Lew, Masoud Vedadi, Wen Hwa Lee, Raymond Hui

Comparative Structural Analysis of Lipid Binding START Domains

Ann-Gerd Thorsell, Wen Hwa Lee, Camilla Persson, Marina I. Siponen, Martina Nilsson, Robert D. Busam, Tetyana Kotenyova, Herwig Schüler, Lari Lehtiö

Structural and Histone Binding Ability Characterizations of Human PWWP Domains

Hong Wu, Hong Zeng, Robert Lam, Wolfram Tempel, Maria F. Amaya, Chao Xu, Ludmila Dombrovski, Wei Qiu, Yanming Wang, Jinrong Min

Structural Studies of the Tandem Tudor Domains of Fragile X Mental Retardation Related Proteins FXR1 and FXR2

Melanie A. Adams-Cioaba, Yahong Guo, ChuanBing Bian, Maria F. Amaya, Robert Lam, Gregory A. Wasney, Masoud Vedadi, Chao Xu, Jinrong Min

High-Affinity Inhibitors of Human NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships

Frank H. Niesen, Lena Schultz, Ajit Jadhav, Chitra Bhatia, Kunde Guo, David J. Maloney, Ewa S. Pilka, Minghua Wang, Udo Oppermann, Tom D. Heightman, Anton Simeonov

The Crystal Structure of the Dachshund Domain of Human SnoN Reveals Flexibility in the Putative Protein Interaction Surface

Tomas Nyman, Lionel Trésaugues, Martin Welin, Lari Lehtiö, Susanne Flodin, Camilla Persson, Ida Johansson, Martin Hammarström, Pär Nordlund

The Crystal Structure of Toxoplasma gondii Pyruvate Kinase 1

Rebecca Bakszt, Amy Wernimont, Abdellah Allali-Hassani, Man Wai Mok, Tanya Hills, Raymond Hui, Juan C. Pizarro

Structural Comparison of Human Mammalian Ste20-Like Kinases

Christopher J. Record, Apirat Chaikuad, Peter Rellos, Sanjan Das, Ashley C. W. Pike, Oleg Fedorov, Brian D. Marsden, Stefan Knapp, Wen Hwa Lee

Structure of the CaMKIIδ/Calmodulin Complex Reveals the Molecular Mechanism of CaMKII Kinase Activation

Peter Rellos, Ashley C. W. Pike, Frank H. Niesen, Eidarus Salah, Wen Hwa Lee, Frank von Delft, Stefan Knapp

Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases

Tara L. Davis, John R. Walker, Valérie Campagna-Slater, Patrick J. Finerty Jr, Ragika Paramanathan, Galina Bernstein, Farrell MacKenzie, Wolfram Tempel, Hui Ouyang, Wen Hwa Lee, Elan Z. Eisenmesser, Sirano Dhe-Paganon

Structural Biology of Human H3K9 Methyltransferases

Hong Wu, Jinrong Min, Vladimir V. Lunin, Tatiana Antoshenko, Ludmila Dombrovski, Hong Zeng, Abdellah Allali-Hassani, Valérie Campagna-Slater, Masoud Vedadi, Cheryl H. Arrowsmith, Alexander N. Plotnikov, Matthieu Schapira

Crystal Structures of the ATPase Domains of Four Human Hsp70 Isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78

Magdalena Wisniewska, Tobias Karlberg, Lari Lehtiö, Ida Johansson, Tetyana Kotenyova, Martin Moche, Herwig Schüler

Crystal Structure of the ATPase Domain of the Human AAA+ Protein Paraplegin/SPG7

Tobias Karlberg, Susanne van den Berg, Martin Hammarström, Johanna Sagemark, Ida Johansson, Lovisa Holmberg-Schiavone, Herwig Schüler

Crystal Structure of the PIM2 Kinase in Complex with an Organoruthenium Inhibitor

Alex N. Bullock, Santina Russo, Ann Amos, Nicholas Pagano, Howard Bregman, Judit É. Debreczeni, Wen Hwa Lee, Frank von Delft, Eric Meggers, Stefan Knapp

Structural Basis for Substrate Specificity in Human Monomeric Carbonyl Reductases

Ewa S. Pilka, Frank H. Niesen, Wen Hwa Lee, Yasser El-Hawari, James E. Dunford, Grazyna Kochan, Vladimir Wsol, Hans-Joerg Martin, Edmund Maser, Udo Oppermann

Crystal Structure of the N-Acetylmannosamine Kinase Domain of GNE

Yufeng Tong, Wolfram Tempel, Lyudmila Nedyalkova, Farrell MacKenzie, Hee-Won Park

Structural Studies of a Four-MBT Repeat Protein MBTD1

Jitka Eryilmaz, Patricia Pan, Maria F. Amaya, Abdellah Allali-Hassani, Aiping Dong, Melanie A. Adams-Cioaba, Farrell MacKenzie, Masoud Vedadi, Jinrong Min