Table of Contents: PLoS Neglected Tropical Diseases: Sleeping Sickness


Image Credit: Pere P. Simarro, World Health Organization
Issue Image

In the February 2011 issue of PLoS Neglected Tropical Diseases, Simarro and colleagues report in "The Human African Trypanosomiasis Control and Surveillance Programme of the World Health Organization 2000-2009: The Way Forward" that new cases of human African trypanosomiasis (HAT), more familiarly known as sleeping sickness, fell below 10,000 in 2009, perhaps signaling the end to this epidemic cycle.

Deputy Editor-in-Chief Serap Aksoy elaborates on this finding in her editorial, titled "Sleeping Sickness Elimination in Sight: Time to Celebrate, Reflect but not Relax." To highlight the existing literature PLoS NTDs authors have contributed to the field, Dr. Aksoy combed the archives to find those articles on HAT that we have published with potential applications for disease control.

Providing access to diagnosis of affected population through mass screening in disease-endemic areas by mobile teams and subsequent treatment has been the basis of the methodology to reduce transmission of human African trypanosomiasis (see Simarro et al., 10.1371/journal.pntd.0001007).



Factory Tsetse Flies Must Behave Like Wild Flies: A Prerequisite for the Sterile Insect Technique

Marc J. B. Vreysen, Khalfan M. Saleh, Renaud Lancelot, Jérémy Bouyer

The Human African Trypanosomiasis Control and Surveillance Programme of the World Health Organization 2000–2009: The Way Forward

Pere P. Simarro, Abdoulaye Diarra, Jose A. Ruiz Postigo, José R. Franco, Jean G. Jannin

NECT Is Next: Implementing the New Drug Combination Therapy for Trypanosoma brucei gambiense Sleeping Sickness

Oliver Yun, Gerardo Priotto, Jacqueline Tong, Laurence Flevaud, François Chappuis

From Innovation to Application

Improved Models of Mini Anion Exchange Centrifugation Technique (mAECT) and Modified Single Centrifugation (MSC) for Sleeping Sickness Diagnosis and Staging

Philippe Büscher, Dieudonné Mumba Ngoyi, Jacques Kaboré, Veerle Lejon, Jo Robays, Vincent Jamonneau, Nicolas Bebronne, Wim Van der Veken, Sylvain Biéler

Research Articles

Bayesian Geostatistical Analysis and Prediction of Rhodesian Human African Trypanosomiasis

Nicola A. Wardrop, Peter M. Atkinson, Peter W. Gething, Eric M. Fèvre, Kim Picozzi, Abbas S. L. Kakembo, Susan C. Welburn

Revisiting the Immune Trypanolysis Test to Optimise Epidemiological Surveillance and Control of Sleeping Sickness in West Africa

Vincent Jamonneau, Bruno Bucheton, Jacques Kaboré, Hamidou Ilboudo, Oumou Camara, Fabrice Courtin, Philippe Solano, Dramane Kaba, Roger Kambire, Kouakou Lingue, Mamadou Camara, Rudy Baelmans, Veerle Lejon, Philippe Büscher

Fexinidazole – A New Oral Nitroimidazole Drug Candidate Entering Clinical Development for the Treatment of Sleeping Sickness

Els Torreele, Bernadette Bourdin Trunz, David Tweats, Marcel Kaiser, Reto Brun, Guy Mazué, Michael A. Bray, Bernard Pécoul

LAMP for Human African Trypanosomiasis: A Comparative Study of Detection Formats

Sally L. Wastling, Kim Picozzi, Abbas S. L. Kakembo, Susan C. Welburn

Phase II Evaluation of Sensitivity and Specificity of PCR and NASBA Followed by Oligochromatography for Diagnosis of Human African Trypanosomiasis in Clinical Samples from D.R. Congo and Uganda

Enock Matovu, Claire M. Mugasa, Rosine Ali Ekangu, Stijn Deborggraeve, George W. Lubega, Thierry Laurent, Gerard J. Schoone, Henk D. Schallig, Philippe Büscher

Population Genetics as a Tool to Select Tsetse Control Strategies: Suppression or Eradication of Glossina palpalis gambiensis in the Niayes of Senegal

Philippe Solano, Dramane Kaba, Sophie Ravel, Naomi A. Dyer, Baba Sall, Marc J. B. Vreysen, Momar T. Seck, Heather Darbyshir, Laetitia Gardes, Martin J. Donnelly, Thierry De Meeûs, Jérémy Bouyer

Prospects for the Development of Odour Baits to Control the Tsetse Flies Glossina tachinoides and G. palpalis s.l.

J. B. Rayaisse, I. Tirados, D. Kaba, S. Y. Dewhirst, J. G. Logan, A. Diarrassouba, E. Salou, M. O. Omolo, P. Solano, M. J. Lehane, J. A. Pickett, G. A. Vale, S. J. Torr, J. Esterhuizen

Phylogeography and Population Structure of Glossina fuscipes fuscipes in Uganda: Implications for Control of Tsetse

Jon S. Beadell, Chaz Hyseni, Patrick P. Abila, Rogers Azabo, John C. K. Enyaru, Johnson O. Ouma, Yassir O. Mohammed, Loyce M. Okedi, Serap Aksoy, Adalgisa Caccone

Spatial Predictions of Rhodesian Human African Trypanosomiasis (Sleeping Sickness) Prevalence in Kaberamaido and Dokolo, Two Newly Affected Districts of Uganda

Nicola A. Batchelor, Peter M. Atkinson, Peter W. Gething, Kim Picozzi, Eric M. Fèvre, Abbas S. L. Kakembo, Susan C. Welburn

Preclinical Assessment of the Treatment of Second-Stage African Trypanosomiasis with Cordycepin and Deoxycoformycin

Suman K. Vodnala, Marcela Ferella, Hilda Lundén-Miguel, Evans Betha, Nick van Reet, Daniel Ndem Amin, Bo Öberg, Björn Andersson, Krister Kristensson, Hans Wigzell, Martin E. Rottenberg

A Combined CXCL10, CXCL8 and H-FABP Panel for the Staging of Human African Trypanosomiasis Patients

Alexandre Hainard, Natalia Tiberti, Xavier Robin, Veerle Lejon, Dieudonné Mumba Ngoyi, Enock Matovu, John Charles Enyaru, Catherine Fouda, Joseph Mathu Ndung'u, Frédérique Lisacek, Markus Müller, Natacha Turck, Jean-Charles Sanchez

Prospects for Developing Odour Baits To Control Glossina fuscipes spp., the Major Vector of Human African Trypanosomiasis

Maurice O. Omolo, Ahmed Hassanali, Serge Mpiana, Johan Esterhuizen, Jenny Lindh, Mike J. Lehane, Philippe Solano, Jean Baptiste Rayaisse, Glyn A. Vale, Steve J. Torr, Inaki Tirados

Loop-Mediated Isothermal Amplification (LAMP) Method for Rapid Detection of Trypanosoma brucei rhodesiense

Zablon Kithinji Njiru, Andrew Stanislaw John Mikosza, Tanya Armstrong, John Charles Enyaru, Joseph Mathu Ndung'u, Andrew Richard Christopher Thompson