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Structural Biology and Human Health: Medically Relevant Proteins from the SGC

This collection of articles represents some of the research highlights from the SGC (www.thesgc.org ). The SGC is an international public-private partnership that determines three dimensional structures of medically important proteins from both human and human parasites and places this information into the public domain, free from restrictions on use. The articles describe the structure and further characterisation of the proteins in an easily accessible way. All articles in this collection can be read on-line as interactive documents, where relevant features described in the text can be visualised as 3D molecular scenes that can be directly manipulated by the reader. New articles will be added to the collection as they are published.

Image Credit: Wen Hwa Lee of the SGC.

Overviews Top

SGC - Structural Biology and Human Health: A New Approach to Publishing Structural Biology Results

Wen Hwa Lee, Julián Atienza-Herrero, Ruben Abagyan, Brian D. Marsden

PLoS ONE:
Published 20 Oct 2009 | info:doi/10.1371/journal.pone.0007675

A New Method for Publishing Three-Dimensional Content

Eugene Raush, Max Totrov, Brian D. Marsden, Ruben Abagyan

PLoS ONE:
Published 20 Oct 2009 | info:doi/10.1371/journal.pone.0007394

Research Articles Top

Structural Comparison of Human Mammalian Ste20-Like Kinases

Christopher J. Record, Apirat Chaikuad, Peter Rellos, Sanjan Das, Ashley C. W. Pike, Oleg Fedorov, Brian D. Marsden, Stefan Knapp, Wen Hwa Lee

PLoS ONE:
Published 06 Aug 2010 | info:doi/10.1371/journal.pone.0011905

Structure of the CaMKIIδ/Calmodulin Complex Reveals the Molecular Mechanism of CaMKII Kinase Activation

Peter Rellos, Ashley C. W. Pike, Frank H. Niesen, Eidarus Salah, Wen Hwa Lee, Frank von Delft, Stefan Knapp

PLoS Biology:
Published 27 Jul 2010 | info:doi/10.1371/journal.pbio.1000426

Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases

Tara L. Davis, John R. Walker, Valérie Campagna-Slater, Patrick J. Finerty Jr, Ragika Paramanathan, Galina Bernstein, Farrell MacKenzie, Wolfram Tempel, Hui Ouyang, Wen Hwa Lee, Elan Z. Eisenmesser, Sirano Dhe-Paganon

PLoS Biology:
Published 27 Jul 2010 | info:doi/10.1371/journal.pbio.1000439

Crystal Structures of the ATPase Domains of Four Human Hsp70 Isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78

Magdalena Wisniewska, Tobias Karlberg, Lari Lehtiö, Ida Johansson, Tetyana Kotenyova, Martin Moche, Herwig Schüler

PLoS ONE:
Published 11 Jan 2010 | info:doi/10.1371/journal.pone.0008625

Structural Biology of Human H3K9 Methyltransferases

Hong Wu, Jinrong Min, Vladimir V. Lunin, Tatiana Antoshenko, Ludmila Dombrovski, Hong Zeng, Abdellah Allali-Hassani, Valérie Campagna-Slater, Masoud Vedadi, Cheryl H. Arrowsmith, Alexander N. Plotnikov, Matthieu Schapira

PLoS ONE:
Published 11 Jan 2010 | info:doi/10.1371/journal.pone.0008570

Crystal Structure of the ATPase Domain of the Human AAA+ Protein Paraplegin/SPG7

Tobias Karlberg, Susanne van den Berg, Martin Hammarström, Johanna Sagemark, Ida Johansson, Lovisa Holmberg-Schiavone, Herwig Schüler

PLoS ONE:
Published 20 Oct 2009 | info:doi/10.1371/journal.pone.0006975

Crystal Structure of the PIM2 Kinase in Complex with an Organoruthenium Inhibitor

Alex N. Bullock, Santina Russo, Ann Amos, Nicholas Pagano, Howard Bregman, Judit É. Debreczeni, Wen Hwa Lee, Frank von Delft, Eric Meggers, Stefan Knapp

PLoS ONE:
Published 20 Oct 2009 | info:doi/10.1371/journal.pone.0007112

Structural Basis for Substrate Specificity in Human Monomeric Carbonyl Reductases

Ewa S. Pilka, Frank H. Niesen, Wen Hwa Lee, Yasser El-Hawari, James E. Dunford, Grazyna Kochan, Vladimir Wsol, Hans-Joerg Martin, Edmund Maser, Udo Oppermann

PLoS ONE:
Published 20 Oct 2009 | info:doi/10.1371/journal.pone.0007113

Crystal Structure of the N-Acetylmannosamine Kinase Domain of GNE

Yufeng Tong, Wolfram Tempel, Lyudmila Nedyalkova, Farrell MacKenzie, Hee-Won Park

PLoS ONE:
Published 20 Oct 2009 | info:doi/10.1371/journal.pone.0007165

Structural Studies of a Four-MBT Repeat Protein MBTD1

Jitka Eryilmaz, Patricia Pan, Maria F. Amaya, Abdellah Allali-Hassani, Aiping Dong, Melanie A. Adams-Cioaba, Farrell MacKenzie, Masoud Vedadi, Jinrong Min

PLoS ONE:
Published 20 Oct 2009 | info:doi/10.1371/journal.pone.0007274