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Epigenetics 2010

Epigenetics is the study of inherited changes in phenotype or gene expression caused by mechanisms other than changes in the underlying DNA sequence. This image represents the structure of a nucleosome. Nucleosomes are thought to carry epigenetically inherited information in the form of covalent modifications of their core histones.

This collection brings together twenty Research Articles published in five PLoS journals in the area of epigenetics during 2010, along with a Research in Translation article and two Primers. They reflect a range of model systems and organisms, and variously offer phenotypic, mechanistic, and chromatin-based insights.

Produced with support from New England Biolabs. The PLoS journal editors have sole responsibility for the content of this collection.

Download: Complete Collection (62 MB PDF).

Image Credit: Wikimedia Commons (http://commons.wikimedia.org/wiki/File:Nucleosome_1KX5_2.png). This image is licensed under the Creative Commons Attribution ShareAlike 3.0 license. In short, you are free to share and make derivative works of the image under the condition that you appropriately attribute it, and that you distribute it only under the same, a similar, or a compatible license.

Primers Top

Centromeres Convert but Don't Cross

Paul B. Talbert, Steven Henikoff

PLoS Biology:
Published 09 Mar 2010 | info:doi/10.1371/journal.pbio.1000326

Genomic Responses to Abnormal Gene Dosage: The X Chromosome Improved on a Common Strategy

Xinxian Deng, Christine M. Disteche

PLoS Biology:
Published 23 Feb 2010 | info:doi/10.1371/journal.pbio.1000318

Research in Translation Top

Epigenetic Epidemiology of Common Complex Disease: Prospects for Prediction, Prevention, and Treatment

Caroline L. Relton, George Davey Smith

PLoS Hub for Clinical Trials, PLoS Medicine:
Published 26 Oct 2010 | info:doi/10.1371/journal.pmed.1000356

Research Articles Top

Spatial Epigenetic Control of Mono- and Bistable Gene Expression

János Z. Kelemen, Prasuna Ratna, Simone Scherrer, Attila Becskei

PLoS Biology:
Published 16 Mar 2010 | info:doi/10.1371/journal.pbio.1000332

Widespread Gene Conversion in Centromere Cores

Jinghua Shi, Sarah E. Wolf, John M. Burke, Gernot G. Presting, Jeffrey Ross-Ibarra, R. Kelly Dawe

PLoS Biology:
Published 09 Mar 2010 | info:doi/10.1371/journal.pbio.1000327

Expression in Aneuploid Drosophila S2 Cells

Yu Zhang, John H. Malone, Sara K. Powell, Vipul Periwal, Eric Spana, David M. MacAlpine, Brian Oliver

PLoS Biology:
Published 23 Feb 2010 | info:doi/10.1371/journal.pbio.1000320

2-D Structure of the A Region of Xist RNA and Its Implication for PRC2 Association

Sylvain Maenner, Magali Blaud, Laetitia Fouillen, Anne Savoye, Virginie Marchand, Agnès Dubois, Sarah Sanglier-Cianférani, Alain Van Dorsselaer, Philippe Clerc, Philip Avner, Athanase Visvikis, Christiane Branlant

PLoS Biology:
Published 05 Jan 2010 | info:doi/10.1371/journal.pbio.1000276

Poised Transcription Factories Prime Silent uPA Gene Prior to Activation

Carmelo Ferrai, Sheila Q. Xie, Paolo Luraghi, Davide Munari, Francisco Ramirez, Miguel R. Branco, Ana Pombo, Massimo P. Crippa

PLoS Biology:
Published 05 Jan 2010 | info:doi/10.1371/journal.pbio.1000270

Computational Analysis of Whole-Genome Differential Allelic Expression Data in Human

James R. Wagner, Bing Ge, Dmitry Pokholok, Kevin L. Gunderson, Tomi Pastinen, Mathieu Blanchette

PLoS Computational Biology:
Published 08 Jul 2010 | info:doi/10.1371/journal.pcbi.1000849

Altering a Histone H3K4 Methylation Pathway in Glomerular Podocytes Promotes a Chronic Disease Phenotype

Gaelle M. Lefevre, Sanjeevkumar R. Patel, Doyeob Kim, Lino Tessarollo, Gregory R. Dressler

PLoS Genetics:
Published 28 Oct 2010 | info:doi/10.1371/journal.pgen.1001142

The IG-DMR and the MEG3-DMR at Human Chromosome 14q32.2: Hierarchical Interaction and Distinct Functional Properties as Imprinting Control Centers

Masayo Kagami, Maureen J. O'Sullivan, Andrew J. Green, Yoshiyuki Watabe, Osamu Arisaka, Nobuhide Masawa, Kentarou Matsuoka, Maki Fukami, Keiko Matsubara, Fumiko Kato, Anne C. Ferguson-Smith, Tsutomu Ogata

PLoS Genetics:
Published 17 Jun 2010 | info:doi/10.1371/journal.pgen.1000992

siRNA–Mediated Methylation of Arabidopsis Telomeres

Jan Vrbsky, Svetlana Akimcheva, J. Matthew Watson, Thomas L. Turner, Lucia Daxinger, Boris Vyskot, Werner Aufsatz, Karel Riha

PLoS Genetics:
Published 10 Jun 2010 | info:doi/10.1371/journal.pgen.1000986

Initial Genomics of the Human Nucleolus

Attila Németh, Ana Conesa, Javier Santoyo-Lopez, Ignacio Medina, David Montaner, Bálint Péterfia, Irina Solovei, Thomas Cremer, Joaquin Dopazo, Gernot Längst

PLoS Genetics:
Published 26 Mar 2010 | info:doi/10.1371/journal.pgen.1000889

Nuclear Pore Proteins Nup153 and Megator Define Transcriptionally Active Regions in the Drosophila Genome

Juan M. Vaquerizas, Ritsuko Suyama, Jop Kind, Kota Miura, Nicholas M. Luscombe, Asifa Akhtar

PLoS Genetics:
Published 12 Feb 2010 | info:doi/10.1371/journal.pgen.1000846

Maternal Ethanol Consumption Alters the Epigenotype and the Phenotype of Offspring in a Mouse Model

Nina Kaminen-Ahola, Arttu Ahola, Murat Maga, Kylie-Ann Mallitt, Paul Fahey, Timothy C. Cox, Emma Whitelaw, Suyinn Chong

PLoS Genetics:
Published 15 Jan 2010 | info:doi/10.1371/journal.pgen.1000811

Epigenetic Analysis of KSHV Latent and Lytic Genomes

Zsolt Toth, Dennis T. Maglinte, Sun Hwa Lee, Hye-Ra Lee, Lai-Yee Wong, Kevin F. Brulois, Stacy Lee, Jonathan D. Buckley, Peter W. Laird, Victor E. Marquez, Jae U. Jung

PLoS Pathogens:
Published 22 Jul 2010 | info:doi/10.1371/journal.ppat.1001013

The Epigenetic Landscape of Latent Kaposi Sarcoma-Associated Herpesvirus Genomes

Thomas Günther, Adam Grundhoff

PLoS Pathogens:
Published 03 Jun 2010 | info:doi/10.1371/journal.ppat.1000935

A New Nuclear Function of the Entamoeba histolytica Glycolytic Enzyme Enolase: The Metabolic Regulation of Cytosine-5 Methyltransferase 2 (Dnmt2) Activity

Ayala Tovy, Rama Siman Tov, Ricarda Gaentzsch, Mark Helm, Serge Ankri

PLoS Pathogens:
Published 19 Feb 2010 | info:doi/10.1371/journal.ppat.1000775