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Genetically Modified Insect Collection

The January 2012 issue of PLoS Neglected Tropical Diseases presents an Editorial, a Viewpoint, and two accompanying Expert Commentaries that focus on the application of genetically modified (GM) insects for control of animal and plant diseases. These articles describe the technological advances these tools represent, the regulatory framework, and the societal dialogue that is necessary for their wide-scale application for disease control. Here, we have assembled a collection of articles recently published in the PLoS journals that describe the technical and applied aspects of GM insects. We have also included articles that are not strictly GM, but aim to modify the disease transmission traits of insects through the use of symbiotic microbes.

www.ploscollections.org/GMInsect

Image Credit: James Gathany, Centers for Disease Control and Prevention

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Editorial Top

Control Using Genetically Modified Insects Poses Problems for Regulators

Michael J. Lehane, Serap Aksoy

PLoS Neglected Tropical Diseases:
Published 31 Jan 2012 | info:doi/10.1371/journal.pntd.0001495

Viewpoints Top

Scientific Standards and the Regulation of Genetically Modified Insects

R. Guy Reeves, Jai A. Denton, Fiammetta Santucci, Jarosław Bryk, Floyd A. Reed

PLoS Neglected Tropical Diseases:
Published 31 Jan 2012 | info:doi/10.1371/journal.pntd.0001502

Expert Commentaries Top

Appropriate Regulation of GM Insects

Luke Alphey, Camilla Beech

PLoS Neglected Tropical Diseases:
Published 31 Jan 2012 | info:doi/10.1371/journal.pntd.0001496

Science, Regulation, and Precedent for Genetically Modified Insects

John D. Mumford

PLoS Neglected Tropical Diseases:
Published 31 Jan 2012 | info:doi/10.1371/journal.pntd.0001504

Research Articles Top

Engineered Anopheles Immunity to Plasmodium Infection

Yuemei Dong, Suchismita Das, Chris Cirimotich, Jayme A. Souza-Neto, Kyle J. McLean, George Dimopoulos

PLoS Pathogens:
Published 22 Dec 2011 | info:doi/10.1371/journal.ppat.1002458

Transcriptome Analysis of Aedes aegypti Transgenic Mosquitoes with Altered Immunity

Zhen Zou, Jayme Souza-Neto, Zhiyong Xi, Vladimir Kokoza, Sang Woon Shin, George Dimopoulos, Alexander Raikhel

PLoS Pathogens:
Published 17 Nov 2011 | info:doi/10.1371/journal.ppat.1002394

A New Powerful Method for Site-Specific Transgene Stabilization Based on Chromosomal Double-Strand Break Repair

Artem Tkachuk, Maria Kim, Oksana Kravchuk, Mikhail Savitsky

PLoS ONE:
Published 17 Oct 2011 | info:doi/10.1371/journal.pone.0026422

Cost of Mating and Insemination Capacity of a Genetically Modified Mosquito Aedes aegypti OX513A Compared to Its Wild Type Counterpart

Irka Bargielowski, Luke Alphey, Jacob C. Koella

PLoS ONE:
Published 11 Oct 2011 | info:doi/10.1371/journal.pone.0026086

A Model Framework to Estimate Impact and Cost of Genetics-Based Sterile Insect Methods for Dengue Vector Control

Nina Alphey, Luke Alphey, Michael B. Bonsall

PLoS ONE:
Published 05 Oct 2011 | info:doi/10.1371/journal.pone.0025384

Field Performance of a Genetically Engineered Strain of Pink Bollworm

Gregory S. Simmons, Andrew R. McKemey, Neil I. Morrison, Sinead O'Connell, Bruce E. Tabashnik, John Claus, Guoliang Fu, Guolei Tang, Mickey Sledge, Adam S. Walker, Caroline E. Phillips, Ernie D. Miller, Robert I. Rose, Robert T. Staten, Christl A. Donnelly, Luke Alphey

PLoS ONE:
Published 13 Sep 2011 | info:doi/10.1371/journal.pone.0024110

Comparison of Life History Characteristics of the Genetically Modified OX513A Line and a Wild Type Strain of Aedes aegypti

Irka Bargielowski, Derric Nimmo, Luke Alphey, Jacob C. Koella

PLoS ONE:
Published 17 Jun 2011 | info:doi/10.1371/journal.pone.0020699

Wolbachia Infections Are Virulent and Inhibit the Human Malaria Parasite Plasmodium Falciparum in Anopheles Gambiae

Grant L. Hughes, Ryuichi Koga, Ping Xue, Takema Fukatsu, Jason L. Rasgon

PLoS Pathogens:
Published 19 May 2011 | info:doi/10.1371/journal.ppat.1002043

Strategies for Introducing Wolbachia to Reduce Transmission of Mosquito-Borne Diseases

Penelope A. Hancock, Steven P. Sinkins, H. Charles J. Godfray

PLoS Neglected Tropical Diseases:
Published 26 Apr 2011 | info:doi/10.1371/journal.pntd.0001024

Engineered Resistance to Plasmodium falciparum Development in Transgenic Anopheles stephensi

Alison T. Isaacs, Fengwu Li, Nijole Jasinskiene, Xiaoguang Chen, Xavier Nirmala, Osvaldo Marinotti, Joseph M. Vinetz, Anthony A. James

PLoS Pathogens:
Published 21 Apr 2011 | info:doi/10.1371/journal.ppat.1002017

Site-Specific Integration and Expression of an Anti-Malarial Gene in Transgenic Anopheles gambiae Significantly Reduces Plasmodium Infections

Janet M. Meredith, Sanjay Basu, Derric D. Nimmo, Isabelle Larget-Thiery, Emma L. Warr, Ann Underhill, Clare C. McArthur, Victoria Carter, Hilary Hurd, Catherine Bourgouin, Paul Eggleston

PLoS ONE:
Published 25 Jan 2011 | info:doi/10.1371/journal.pone.0014587

Wolbachia Stimulates Immune Gene Expression and Inhibits Plasmodium Development in Anopheles gambiae

Zakaria Kambris, Andrew M. Blagborough, Sofia B. Pinto, Marcus S. C. Blagrove, H. Charles J. Godfray, Robert E. Sinden, Steven P. Sinkins

PLoS Pathogens:
Published 07 Oct 2010 | info:doi/10.1371/journal.ppat.1001143

piggybac- and PhiC31-Mediated Genetic Transformation of the Asian Tiger Mosquito, Aedes albopictus (Skuse)

Geneviève M. C. Labbé, Derric D. Nimmo, Luke Alphey

PLoS Neglected Tropical Diseases:
Published 17 Aug 2010 | info:doi/10.1371/journal.pntd.0000788

A Virulent Wolbachia Infection Decreases the Viability of the Dengue Vector Aedes aegypti during Periods of Embryonic Quiescence

Conor J. McMeniman, Scott L. O'Neill

PLoS Neglected Tropical Diseases:
Published 13 Jul 2010 | info:doi/10.1371/journal.pntd.0000748

Targeting the X Chromosome during Spermatogenesis Induces Y Chromosome Transmission Ratio Distortion and Early Dominant Embryo Lethality in Anopheles gambiae

Nikolai Windbichler, Philippos Aris Papathanos, Andrea Crisanti

PLoS Genetics:
Published 05 Dec 2008 | info:doi/10.1371/journal.pgen.1000291