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Structural Biology and Human Health: Medically Relevant Proteins from the SGC

This collection of articles represents some of the research highlights from the SGC (www.thesgc.org ). The SGC is an international public-private partnership that determines three dimensional structures of medically important proteins from both human and human parasites and places this information into the public domain, free from restrictions on use. The articles describe the structure and further characterisation of the proteins in an easily accessible way. All articles in this collection can be read on-line as interactive documents, where relevant features described in the text can be visualised as 3D molecular scenes that can be directly manipulated by the reader. New articles will be added to the collection as they are published.

Image Credit: Wen Hwa Lee of the SGC.

Overviews Top

A New Method for Publishing Three-Dimensional Content

Eugene Raush, Max Totrov, Brian D. Marsden, Ruben Abagyan

PLoS ONE:
Published 20 Oct 2009 | info:doi/10.1371/journal.pone.0007394

SGC - Structural Biology and Human Health: A New Approach to Publishing Structural Biology Results

Wen Hwa Lee, Julián Atienza-Herrero, Ruben Abagyan, Brian D. Marsden

PLoS ONE:
Published 20 Oct 2009 | info:doi/10.1371/journal.pone.0007675

Synopsis Top

Structure of Signaling Enzyme Reveals How Calcium Turns It On

Richard Robinson

PLoS Biology:
Published 27 Jul 2010 | info:doi/10.1371/journal.pbio.1000427

Research Articles Top

Oligomeric Structure of the MALT1 Tandem Ig-Like Domains

Liyan Qiu, Sirano Dhe-Paganon

PLoS ONE:
Published 23 Sep 2011 | info:doi/10.1371/journal.pone.0023220

Characterization of 14-3-3 Proteins from Cryptosporidium parvum

Stephen J. Brokx, Amy K. Wernimont, Aiping Dong, Gregory A. Wasney, Yu-Hui Lin, Jocelyne Lew, Masoud Vedadi, Wen Hwa Lee, Raymond Hui

PLoS ONE:
Published 11 Aug 2011 | info:doi/10.1371/journal.pone.0014827

Comparative Structural Analysis of Lipid Binding START Domains

Ann-Gerd Thorsell, Wen Hwa Lee, Camilla Persson, Marina I. Siponen, Martina Nilsson, Robert D. Busam, Tetyana Kotenyova, Herwig Schüler, Lari Lehtiö

PLoS ONE:
Published 30 Jun 2011 | info:doi/10.1371/journal.pone.0019521

Structural and Histone Binding Ability Characterizations of Human PWWP Domains

Hong Wu, Hong Zeng, Robert Lam, Wolfram Tempel, Maria F. Amaya, Chao Xu, Ludmila Dombrovski, Wei Qiu, Yanming Wang, Jinrong Min

PLoS ONE:
Published 20 Jun 2011 | info:doi/10.1371/journal.pone.0018919

Structural Studies of the Tandem Tudor Domains of Fragile X Mental Retardation Related Proteins FXR1 and FXR2

Melanie A. Adams-Cioaba, Yahong Guo, ChuanBing Bian, Maria F. Amaya, Robert Lam, Gregory A. Wasney, Masoud Vedadi, Chao Xu, Jinrong Min

PLoS ONE:
Published 02 Nov 2010 | info:doi/10.1371/journal.pone.0013559

High-Affinity Inhibitors of Human NAD⁺-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships

Frank H. Niesen, Lena Schultz, Ajit Jadhav, Chitra Bhatia, Kunde Guo, David J. Maloney, Ewa S. Pilka, Minghua Wang, Udo Oppermann, Tom D. Heightman, Anton Simeonov

PLoS ONE:
Published 02 Nov 2010 | info:doi/10.1371/journal.pone.0013719

The Crystal Structure of the Dachshund Domain of Human SnoN Reveals Flexibility in the Putative Protein Interaction Surface

Tomas Nyman, Lionel Trésaugues, Martin Welin, Lari Lehtiö, Susanne Flodin, Camilla Persson, Ida Johansson, Martin Hammarström, Pär Nordlund

PLoS ONE:
Published 23 Sep 2010 | info:doi/10.1371/journal.pone.0012907

The Crystal Structure of Toxoplasma gondii Pyruvate Kinase 1

Rebecca Bakszt, Amy Wernimont, Abdellah Allali-Hassani, Man Wai Mok, Tanya Hills, Raymond Hui, Juan C. Pizarro

PLoS ONE:
Published 14 Sep 2010 | info:doi/10.1371/journal.pone.0012736

Structural Comparison of Human Mammalian Ste20-Like Kinases

Christopher J. Record, Apirat Chaikuad, Peter Rellos, Sanjan Das, Ashley C. W. Pike, Oleg Fedorov, Brian D. Marsden, Stefan Knapp, Wen Hwa Lee

PLoS ONE:
Published 06 Aug 2010 | info:doi/10.1371/journal.pone.0011905

Structure of the CaMKIIδ/Calmodulin Complex Reveals the Molecular Mechanism of CaMKII Kinase Activation

Peter Rellos, Ashley C. W. Pike, Frank H. Niesen, Eidarus Salah, Wen Hwa Lee, Frank von Delft, Stefan Knapp

PLoS Biology:
Published 27 Jul 2010 | info:doi/10.1371/journal.pbio.1000426

Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases

Tara L. Davis, John R. Walker, Valérie Campagna-Slater, Patrick J. Finerty Jr, Ragika Paramanathan, Galina Bernstein, Farrell MacKenzie, Wolfram Tempel, Hui Ouyang, Wen Hwa Lee, Elan Z. Eisenmesser, Sirano Dhe-Paganon

PLoS Biology:
Published 27 Jul 2010 | info:doi/10.1371/journal.pbio.1000439

Structural Biology of Human H3K9 Methyltransferases

Hong Wu, Jinrong Min, Vladimir V. Lunin, Tatiana Antoshenko, Ludmila Dombrovski, Hong Zeng, Abdellah Allali-Hassani, Valérie Campagna-Slater, Masoud Vedadi, Cheryl H. Arrowsmith, Alexander N. Plotnikov, Matthieu Schapira

PLoS ONE:
Published 11 Jan 2010 | info:doi/10.1371/journal.pone.0008570

Crystal Structures of the ATPase Domains of Four Human Hsp70 Isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78

Magdalena Wisniewska, Tobias Karlberg, Lari Lehtiö, Ida Johansson, Tetyana Kotenyova, Martin Moche, Herwig Schüler

PLoS ONE:
Published 11 Jan 2010 | info:doi/10.1371/journal.pone.0008625