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Research Article

Non-Invasive Mapping of the Gastrointestinal Microbiota Identifies Children with Inflammatory Bowel Disease

  • Eliseo Papa,

    Affiliation: Harvard/MIT Health Science and Technology Institute, Cambridge, Massachusetts, United States of America

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  • Michael Docktor,

    Affiliation: Inflammatory Bowel Disease Center, Children’s Hospital Boston, Boston, Massachusetts, United States of America

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  • Christopher Smillie,

    Affiliation: Computational and Systems Biology Initiative, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Sarah Weber,

    Affiliation: Inflammatory Bowel Disease Center, Children’s Hospital Boston, Boston, Massachusetts, United States of America

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  • Sarah P. Preheim,

    Affiliation: Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Dirk Gevers,

    Affiliation: The Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, United States of America

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  • Georgia Giannoukos,

    Affiliation: The Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, United States of America

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  • Dawn Ciulla,

    Affiliation: The Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, United States of America

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  • Diana Tabbaa,

    Affiliation: The Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, United States of America

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  • Jay Ingram,

    Affiliation: Inflammatory Bowel Disease Center, Children’s Hospital Boston, Boston, Massachusetts, United States of America

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  • David B. Schauer †,

    † Deceased.

    Affiliations: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Doyle V. Ward,

    Affiliation: The Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, United States of America

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  • Joshua R. Korzenik,

    Affiliation: Gastrointestinal Unit, Center for Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Ramnik J. Xavier,

    Affiliations: The Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, United States of America, Gastrointestinal Unit, Center for Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Computational and Integrative Biology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Athos Bousvaros equal contributor mail,

    equal contributor Contributed equally to this work with: Athos Bousvaros, Eric J. Alm

    athos.bousvaros@childrens.harvard.edu (AB); ejalm@mit.edu (EJA)

    Affiliation: Inflammatory Bowel Disease Center, Children’s Hospital Boston, Boston, Massachusetts, United States of America

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  • Eric J. Alm equal contributor mail

    equal contributor Contributed equally to this work with: Athos Bousvaros, Eric J. Alm

    athos.bousvaros@childrens.harvard.edu (AB); ejalm@mit.edu (EJA)

    Affiliations: Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, The Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts, United States of America, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Published: June 29, 2012
  • DOI: 10.1371/journal.pone.0039242
  • Published in PLOS ONE

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