Citation: Rahman A, Surkan PJ, Cayetano CE, Rwagatare P, Dickson KE (2013) Grand Challenges: Integrating Maternal Mental Health into Maternal and Child Health Programmes. PLoS Med 10(5): e1001442. doi:10.1371/journal.pmed.1001442
Published: May 7, 2013
Copyright: © 2013 Rahman et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: No direct funding was received for this study. The authors were personally salaried by their institutions during the period of writing (though no specific salary was set aside or given for the writing of this paper).
Competing interests: The authors have declared that no competing interests exist.
Abbreviations: LMICs, low- and middle-income countries; MCH, maternal and child health
Provenance: Not commissioned; externally peer reviewed.
- Integrating maternal mental health care will help advance maternal and child health (MCH) status.
- Misconceptions regarding maternal depression are obstacles to the integration of mental health initiatives in MCH programmes.
- Myths about maternal mental health include the beliefs that: maternal depression is rare, not relevant to MCH programmes, can only be treated by specialists, and its incorporation into MCH programmes is difficult.
- Collaboration between policy makers in mental health and those in MCH is imperative for action that will advance maternal and child health status.
- Strategies to improve maternal mental health have to be linked to broader development goals, including poverty reduction and gender empowerment.
- This paper is the second in a series of five articles providing a global perspective on integrating mental health.
Over the last decade, a number of influential organisations have called for the integration of mental, neurological and substance use (MNS) disorders into large scale public health programmes . Although progress at the implementation level has been slow, the development of a number of evidence-based, potentially scalable interventions in the MNS field  provides new impetus to develop strategies for integration with broader programmes.
The World Health Organization defines maternal mental health as “a state of well-being in which a mother realizes her own abilities, can cope with the normal stresses of life, can work productively and fruitfully and is able to make a contribution to her community” . Globally, in women of child-bearing age, depression accounts for the largest proportion of the burden associated with mental or neurological disorders , (Box 1). In addition to the economic and human costs of maternal depression, children of depressed mothers are at risk for health, developmental, and behavioral problems , thereby contributing to inter-generational disadvantage that accumulates throughout the life span. Addressing mental health concerns such as maternal depression could play an important role in achieving the Millennium Development Goals set by the United Nations (three out of the eight goals refer specifically to women and children) . However, mental health care remains conspicuous by its absence in large scale global maternal and child health (MCH) programmes. Critical obstacles include a number of misconceptions, or myths, about maternal depression. These myths have important consequences, depriving many mothers of their basic right to health and well-being, and preventing their children from reaching their full developmental potential.
Box 1. Public Health Dimensions of Maternal Depression
- The second leading cause of disease burden in women worldwide, following infections and parasitic diseases
- Presents with low mood, loss of interest or pleasure, feelings of guilt or low self-worth, disturbed sleep or appetite, low energy, and poor concentration – symptoms that profoundly affect maternal functioning and role
- Can become chronic or recurrent and leads to substantial impairments in the mother's ability for child care
- Has long-term negative effects on infant physical and cognitive development
- Can lead to suicide – a leading cause of mortality in women of child-bearing age
In this paper, one in a five-part series, we examine the state of the field of maternal mental health and consider the challenges as well as the opportunities for integration into MCH programmes.
Misconceptions about Maternal Mental Health
Myth 1: Maternal Depression is Rare
A common perception is that depression is a construct of affluent Western societies that is infrequent or non-existent in traditional communities. Perinatal depression (during pregnancy and in the year after birth) has been reported in all cultures. Rates vary considerably, but the average in high-income countries about 10% to 15% . A recent meta-analysis shows that the rates in low- and middle-income countries (LMICs) are even higher, ranging from 18% to 25% . Contributing factors related to depression in women include poverty and persistent poor health; a poor relationship with a partner (including intimate partner violence); insufficient practical or emotional support from the family; few confiding relationships and lack of assistance in crises; social adversity; limited control or participation in financial decisions or reproductive health, including crowded living conditions and lack of employment; and coincidental adverse life events, such as financial difficulties, unwanted pregnancy, or illness in the child ,.
Myth 2: Maternal Depression is Not Relevant to MCH Programmes
Depression is the leading contributor to the global burden of disease (more years of life lived with disability, reduced productivity including unemployment, increased physical illness, increased health expenditure, impact on families and caregivers, and premature mortality) . Strong evidence shows that maternal depression, especially amongst those experiencing social disadvantage, is linked to poor outcomes in infants. Although some studies have not found associations or only found them in subgroups –, others show strong and independent associations with pre-term birth , low birthweight  and undernutrition in the first year of life , higher rates of diarrheal diseases, and early cessation of breastfeeding . Depressive symptoms in low-income pregnant women and mothers have been associated with use of tobacco, alcohol, and illicit drugs ; adverse birth outcomes ; chronic health problems ; low maternal self-esteem ,; and parenting difficulties . The strength of associations vary across studies, however, which could be attributable to social and cultural differences between populations as well as differences and quality of the study designs. Notably, one review indicated that children of depressed mothers have significantly poorer long-term cognitive development; have higher rates of antisocial behaviour, hyperactivity and attention difficulties; and more frequently experience emotional problems . Nonetheless, despite this adversity, many children remain physically healthy and develop normally, demonstrating resilience of maternal care and child development.
Suicide, strongly associated with depression, is a leading contributor to maternal mortality globally. Maternal depression and suicide are strongly associated with gender-based violence; i.e., more than one fifth of women who have experienced violence attempt suicide . Suicidality – thoughts of suicide or actual self-harm – occurs in up to 20% of mothers in LMICs and from 5% to 14%in high-income countries , and rates are even higher in displaced populations . It is common in young women and associated with abuse and stress that might be caused by such events as unwanted pregnancy.
Myth 3: Only Specialists Can Treat Maternal Depression
“Talking” or psychological therapies typically are a front-line treatment for depression. Only a minority of individuals with depression will require anti-depressant medication. Psychological therapies include cognitive behavioral therapy, interpersonal therapy, supportive therapy, and group therapy. Systematic reviews from high-income countries provide evidence of the effectiveness of both psychological therapies and pharmacotherapy in the treatment of perinatal depression .
Over the last decade, the evidence for the effectiveness of non-mental health specialist-led interventions (e.g., involving nurses, health visitors, and midwives) in high-income countries has been building –. Efforts to improve maternal mental health through such interventions in developing countries are promising. Several successful randomized controlled trials have been delivered by lay health workers, a critical resource in settings in which formally trained health professionals are often scarce. Studies where maternal mental health was delivered effectively by non-specialists are summarized in Table 1 –.
Table 1. Effective Interventions for Maternal Mental Health Integrated into Maternal and Child Health.doi:10.1371/journal.pmed.1001442.t001
Myth 4: It is Not Possible to Integrate Mental Health Care into MCH Programmes
Policy makers fear that mental health interventions will divert the energies of health care staff and dilute the impact of other “priority” interventions. This view fails to take into account the holistic nature of health and erroneously propagates the defunct theory of “mind-body” dualism. Most current evidence demonstrates the inter-connectedness of physical and mental health and suggests that integrated interventions can achieve synergistic results .
Examples of community-based trials with a maternal mental health component integrated into a MCH programme – (Table 1) and a case study demonstrating that the screening and management of maternal mental disorders can be integrated successfully into an existing health system at a facility level  (Box 2) build a strong case for integration of mental health care into MCH programmes. The studies in Table 1, all examples of community-based interventions, have common elements that make them more amenable to integration. Some of these elements are described in the formative research to develop the Thinking Healthy Programme in Pakistan : (a) The intervention has a child-focus, thus ensuring buy-in from the families, and avoiding stigmatization; (b) It is woven into the routine work of the community health worker so it is not seen as an extra burden but, being delivered alongside normal duties, is seen to support his or her routine work; and (c) The intervention itself is simple and culturally appropriate and employs robust and supportive training and supervision processes. The Thinking Healthy Programme has been further adapted so that it can be used universally for all women rather than only depressed women.
Box 2. Case Study of Integration of a Stepped Care Intervention with a Facility-based MCH Programme in Urban South Africa 
Neither routine screening nor treatment of maternal mental disorders are available in primary care settings in South Africa. The Perinatal Mental Health Project, based at the Mowbray Maternity Hospital in the Western Cape Province of South Africa, developed a stepped care intervention for maternal mental health that is integrated into antenatal care. Mowbray Maternity Hospital is a secondary level maternity hospital, linked to the University of Cape Town, and is located centrally within the city. The Perinatal Mental Health Project services are based at the hospital within the Midwife Obstetric Unit, which provides a primary level antenatal clinic. Midwives at the Midwife Obstetric Unit are trained to screen women routinely for maternal mood disorders during their antenatal visits. Women in whom screening yields positive findings are referred to on-site counsellors who also act as case managers. When specialist intervention is indicated, women are referred to an on-site psychiatrist. The Perinatal Mental Health Project works directly with facility managers and health workers through collaborative partnerships, focusing on problem solving and capacity development in the primary health care system. Over a 3-year period, 90% of all women attending antenatal care in the maternity clinic were offered mental health screening with 95% uptake. Of those screened, 32% qualified, of which 47% received counselling through the programme.
A number of important lessons have been learned from this programme: (a) maternity health workers may be trained to screen for and refer women with mental distress in low-resource primary care settings; (b) training programmes that address and support the mental health needs of health workers may help staff to manage their workload and prevent compassion fatigue and “burn out”; (c) on-site screening and counselling fosters the establishment of efficient referral mechanisms and access to mental health care often lacking in maternity settings in LMICS; (d) on-site, integrated mental health services increase access for women who have scarce resources and competing health, family, and economic priorities; e) coordinating mental health visits with subsequent antenatal visits further facilitates access for women with insufficient resources.
The challenges to integrating maternal mental health interventions at scale remain substantial. In LMICs, the main barriers include resource allocation, lack of human resource, and weak health systems ,. Globally, a major barrier remains the social exclusion and negative attitudes attached to mental illnesses – a problem as much of the public health professionals as of the communities they serve.
The Way Forward
In 2011, the Grand Challenges in Global Mental Health, an initiative of a consortium of researchers, advocates, and clinicians, announced priorities for improving the lives of people with mental illness around the world and called for urgent action and investment . The principles underlining the setting of such priorities are to use a life-course approach, system-wide approaches to address suffering, and evidence-based interventions, and to understand the environmental context in which illness occurs and services are delivered. We believe these principles are not limited to mental health but are of direct relevance to all of MCH. Long-term follow-up studies from high-income countries show that the offspring of depressed mothers are at a higher risk of poor mental health and social impairment from early childhood through to adolescence and adulthood, and have an increased risk of mortality from medical causes . While such studies have not been conducted in LMICs, the impact of maternal depression through the life course is likely be even greater, given the strong associations with infant low birthweight and undernutrition. This paper highlights evidence-based interventions that can serve as models for integration into existing health systems to improve not only maternal depression but also immediate perinatal and long-term infant health and developmental outcomes, with likely benefits throughout the life course. The immediate needs are to make policy makers, planners, and politicians aware of the missed opportunity of integrating these interventions into mainstream MCH programmes and to direct both research and implementation funds to meet the challenges of scaling up these promising approaches.
The exercise of defining Grand Challenges provides a framework for future steps in this direction . The Challenges especially relevant to maternal depression in the global MCH context are:
- Enhance collaboration between MCH and mental health programmes, researchers, and practitioners
- Develop ways to integrate screening and core packages of mental health services into routine primary health care (e.g., antenatal visits) and establish effective referral mechanisms
- Further develop effective treatments for use by non-specialists, including lay health workers with minimal training
- Address stigma related to mental illness that could impede the integration of mental health into MCH programmes
- Increase capacity in low- and middle-income countries by creating regional centers for mental health research, education, training, and practice that incorporate the views and needs of local people
- Develop sustainable models to train and increase the number of culturally and ethnically diverse lay and specialist providers to deliver evidence-based services
- Strengthen the mental health component in the training of all health care personnel
- Redesign health systems to integrate maternal depression with other chronic disease care, and create parity between mental and physical illness in terms of investment into research, training, treatment, and prevention
- Incorporate a mental health component into international MCH aid and development programmes
The responsibility to meet these challenges is not the sole duty of the mental health community, but rather it should be shared equally by the MCH researchers and funders. But where does one begin? Firstly, gain recognition at the highest international and national policy forums that mental health and well-being is a generic component of MCH that does not compete with MCH programmes but instead complements them. Secondly, enhance the training and supervision of MCH community and primary care personnel so that they can recognise and treat psychosocial distress and depression in women, enabling them to be more effective health workers. Thirdly, adapt effective interventions to local contexts and strengthen systems of supervision, referral, and continued training at the primary, secondary, and tertiary levels so that the community component is well supported. Finally, it is imperative to invest in research and implementation programmes so that these approaches are refined and scaled-up, leading to improved outcomes of all MCH programmes.
Along with efforts to integrate maternal mental health care into MCH programmes comes the need to pay attention to factors contributing to the high rates of maternal depression, especially in resource-poor settings. Epidemiologic data indicate that the origins of depression in women can be traced to the social circumstances of their lives ,. As Desjarlais and colleagues  eloquently pointed out: “hopelessness, exhaustion, anger and fear grow out of hunger, overwork, violence and economic dependence. Understanding the sources of ill health for women means understanding how cultural and economic forces interact to undermine their social status. If the goal of improving women's well-being from childhood through old age is to be achieved, healthy policies aimed at improving the social status of women are needed along with health policies targeting the entire spectrum of women's health needs”. Integration of maternal mental health into the MCH agenda can provide a universally acceptable “window of opportunity” for creating healthy policies, from education to economic empowerment to legal and political mechanisms that enhance the status of women.
The evidence presented in this paper shows that many outcomes that contribute to infant mortality, such as undernutrition, diarrhoeal disease, immunization, and breastfeeding uptake, have direct associations with maternal mental health. By narrowly fixating on mortality and morbidity targets, and relegating psychosocial well-being to be a peripheral goal, the MCH community is missing an important opportunity and, in the process, depriving millions of mothers and children of their basic right to health. This situation needs to be remedied immediately and urgently.
Wrote the first draft of the manuscript: AR. Contributed to the writing of the manuscript: AR PJS CEC PR KED. ICMJE criteria for authorship read and met: AR PJS CEC PR KED. Agree with manuscript results and conclusions: AR PJS CEC PR KED.
- 1. Collins PY, Insel TR, Chockalingam A, Daar A, Maddox YT (2013) Grand Challenges in global mental health: integration in research, policy, and practice. PLoS Med 10: e1001434 doi:10.1371/journal.pmed.1001434.
- 2. Eaton J, McCay L, Semrau M, Chatterjee S, Baingana F, Araya R, et al. (2011) Scale up of services for mental health in low-income and middle-income countries. Lancet 378(9802): 1592–1603. doi: 10.1016/s0140-6736(11)60891-x
- 3. Herrman H, Saxena S, Moodie R (2006) Promoting mental health: concepts, emerging evidence, practice. Geneva: World Health Organization.
- 4. Prince M, Patel V, Saxena S, Maj M, Maselko J, et al. (2007) No health without mental health. Lancet 370: 859–877. doi: 10.1016/s0140-6736(07)61238-0
- 5. Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, et al. (2012) Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990—2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380: 2163–2196.
- 6. Wachs TD, Black MM, Engle PL (2009) Maternal depression: a global threat to children's health, development, and behavior and to human rights. Child Development Perspectives 3: 51–59. doi: 10.1111/j.1750-8606.2008.00077.x
- 7. Miranda JJ, Patel V (2005) Achieving the Millennium Development Goals: does mental health play a role? PLoS Med 2: e291 doi:10.1371/journal.pmed.0020291.
- 8. O'Hara MW, Swain AM (1996) Rates and risk of postpartum depression—a meta-analysis. International Review of Psychiatry 8: 37–54. doi: 10.3109/09540269609037816
- 9. Fisher J, Cabral de Mello M, Patel V, Rahman A, Tran T, et al. (2012) Prevalence and determinants of common perinatal mental disorders in women in low- and lower-middle-income countries: a systematic review. Bull World Health Organ 90: 139G–149G. doi: 10.2471/blt.11.091850
- 10. Falceto OG, Giugliani ER, Fernandes CL (2004) Influence of parental mental health on early termination of breast-feeding: a case-control study. J Am Board Fam Pract 17(3): 173–183. doi: 10.3122/jabfm.17.3.173
- 11. Annagür A, Annagür BB, Sahin A, Ors R, Kara F (2012) Is maternal depressive symptomatology effective on success of exclusive breastfeeding during postpartum 6 weeks? Breastfeed Med. Epub ahead of print 5 Oct 2012. doi: 10.1089/bfm.2012.0036
- 12. Hoffman S, Hatch MC (2000) Depressive symptomatology during pregnancy: evidence for an association with decreased fetal growth in pregnancies of lower social class women. Health Psychol 19(6): 535–543. doi: 10.1037/0278-622.214.171.1245
- 13. Andersson L, Sundström-Poromaa I, Wulff M, Aström M, Bixo M (2004) Neonatal outcome following maternal antenatal depression and anxiety: a population-based study. Am J Epidemiol 159(9): 872–881. doi: 10.1093/aje/kwh122
- 14. Grote NK, Bridge JA, Gavin AR, Melville JL, Iyengar S, et al. (2010) A meta-analysis of depression during pregnancy and the risk of preterm birth, low birth weight, and intrauterine growth restriction. Arch Gen Psychiatry 67: 1012–1024. doi: 10.1001/archgenpsychiatry.2010.111
- 15. Surkan PJ, Kennedy CE, Hurley KM, Black MM (2011) Maternal depression and early childhood growth in developing countries: systematic review and meta-analysis. Bull World Health Organ 287: 607–615D. doi: 10.2471/blt.11.088187
- 16. Zuckerman B, Amaro H, Bauchner H, Cabral H (1989) Depressive symptoms during pregnancy: relationship to poor health behaviors. Am J Obstet Gynecol 160: 1107–1111. doi: 10.1016/0002-9378(89)90170-1
- 17. Lanzi RG, Pascoe JM, Keltner B, Ramey SL (1999) Correlates of maternal depressive symptoms in a national Head Start programme sample. Arch Pediatr Adolesc Med 153: 801–807. doi: 10.1001/archpedi.153.8.801
- 18. Ritter C, Hobfoll SE, Lavin J, Cameron RP, Hulsizer MR (2000) Stress, psychosocial resources, and depressive symptomatology during pregnancy in low-income, inner-city women. Health Psychol 19: 576–585. doi: 10.1037//0278-6126.96.36.1996
- 19. Turner R, Sorenson A, Turner J (2000) Social contingencies in mental health: a seven year follow-up study of teenage mothers. J Marriage Fam 62: 777–791. doi: 10.1111/j.1741-3737.2000.00777.x
- 20. Albright MB, Tamis-LeMonda CS (2002) Maternal depressive symptoms in relation to dimensions of parenting in low-income mothers. Appl Dev Psycho 16: 24–34. doi: 10.1207/s1532480xads0601_03
- 21. World Health Organization (2009) Mental health aspects of women's reproductive health: a global review of the literature. Geneva: WHO.
- 22. Lindahl V, Pearson JL, Colpe L (2005) Prevalence of suicidality during pregnancy and the postpartum. Arch Womens Ment Health 8: 77–87. doi: 10.1007/s00737-005-0080-1
- 23. Rahman A, Hafeez A (2003) Suicidal feelings run high among mothers in refugee camps: a cross-sectional survey. Acta Psychiatr Scand 108: 392–393. doi: 10.1034/j.1600-0447.2003.00220.x
- 24. Sockol LE, Epperson CN, Barber JP (2011) A meta-analysis of treatments for perinatal depression. Clin Psychol Rev 31: 839–849. doi: 10.1016/j.cpr.2011.03.009
- 25. MacArthur C, Winter HR, Bick DE, Lilford RJ, Lancashire RJ, Knowles H (2003) Redesigning postnatal care: a randomised controlled trial of protocol-based midwifery-led care focused on individual women's physical and psychological health needs. Health Technology Assessment 7(37).
- 26. Lumley J, Watson L, Small R, Brown S, Mitchell C, Gunn J (2006) PRISM (Programme of Resources, Information and Support for Mothers): a community-randomised trial to reduce depression and improve women's physical health six months after birth BMC. Public Health 6: 37.
- 27. Crockett K, Zlotnick C, Davis M, Payne N, Washington R (2008) A depression preventive intervention for rural low-income African-American pregnant women at risk for postpartum depression. Arch Womens Ment Health 11(5–6): 319–325. doi: 10.1007/s00737-008-0036-3
- 28. Morrell CJ, Slade P, Warner R, Paley G, Dixon S, Walters SJ, et al. (2009) Clinical effectiveness of health visitor training in psychologically informed approaches for depression in postnatal women: pragmatic cluster randomised trial in primary care. BMJ 338: a3045. doi: 10.1136/bmj.a3045
- 29. Roman LA, Gardiner JC, Lindsay JK, Moore JS, Luo Z, Baer LJ, et al. (2009) Alleviating perinatal depressive symptoms and stress: a nurse-community health worker randomized trial. Arch Womens Ment Health 12(6): 379–391. doi: 10.1007/s00737-009-0083-4
- 30. Tandon SD, Perry DF, Mendelson T, Kemp K, Leis JA (2011) Preventing perinatal depression in low-income home visiting clients: a randomized controlled trial. Journal of Consulting and Clinical Psychology 79(5): 707–712. doi: 10.1037/a0024895
- 31. Baker-Henningham H, Powell C, Walker S, Grantham-McGregor S (2005) The effect of early stimulation on maternal depression: a cluster randomised controlled trial. Arch Dis Child 90: 1230–1234. doi: 10.1136/adc.2005.073015
- 32. Rahman A, Malik A, Sikander S, Roberts C, Creed F (2008) Cognitive behaviour therapy-based intervention by community health workers for mothers with depression and their infants in rural Pakistan: a cluster-randomised controlled trial. Lancet 372: 902–909. doi: 10.1016/s0140-6736(08)61400-2
- 33. Cooper PJ, Tomlinson M, Swartz L, Landman M, Molteno C, et al. (2009) Improving quality of mother-infant relationship and infant attachment in socioeconomically deprived community in South Africa: randomised controlled trial. BMJ 338: b974. doi: 10.1136/bmj.b974
- 34. Honikman S, van Heyningen T, Field S, Baron E, Tomlinson M (2012) Stepped care for maternal mental health: a case study of the perinatal mental health project in South Africa. PLoS Med 9(5): e1001222 doi:10.1371/journal.pmed.1001222.
- 35. Rahman A (2007) Challenges and opportunities in developing a psychological intervention for perinatal depression in rural Pakistan – a multi-method study. Arch Womens Ment Health 10: 211–219. doi: 10.1007/s00737-007-0193-9
- 36. Saxena S, Thornicroft G, Knapp M, Whiteford H (2007) Resources for mental health: scarcity, inequity and inefficiency. Lancet 370(9590): 878–889. doi: 10.1016/s0140-6736(07)61239-2
- 37. Patel V, Belkin GS, Chockalingam A, Cooper J, Saxena S, et al. (2013) Integrating mental health services into priority health care programs: addressing a grand challenge in global mental health. PLoS Med 10: e1001448 10.1371/journal.pmed.1001448.
- 38. Weissman MM, Wickramaratne P, Nomura Y, Warner V, Pilowsky D, et al. (2006) Offspring of depressed parents: 20 years later. Am J Psychiatry 163: 1001–1008. doi: 10.1176/appi.ajp.163.6.1001
- 39. Collins PY, Patel V, Joestl SS, March D, Insel TR, Daar AS, et al. (2011) Grand challenges in global mental health. Nature 475(7354): 27–30. doi: 10.1038/475027a
- 40. Desjarlais R, Eisenberg L, Good B, Kleinman A (1995) World mental health: problems and priorities in low income countries. Oxford: Oxford University Press.