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Research Article

Genome Sequence of the Saprophyte Leptospira biflexa Provides Insights into the Evolution of Leptospira and the Pathogenesis of Leptospirosis

  • Mathieu Picardeau equal contributor,

    equal contributor Contributed equally to this work with: Mathieu Picardeau, Dieter M. Bulach

    Affiliation: Unité de Biologie des Spirochètes, Institut Pasteur, Paris, France

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  • Dieter M. Bulach equal contributor,

    equal contributor Contributed equally to this work with: Mathieu Picardeau, Dieter M. Bulach

    Affiliations: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia, Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton, Victoria, Australia, Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Christiane Bouchier,

    Affiliation: Plate-forme Génomique, Institut Pasteur, Paris, France

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  • Richard L. Zuerner,

    Affiliation: Bacterial Diseases of Livestock Research Unit, National Animal Disease Center (NADC), Agricultural Research Service (ARS), United States Department of Agriculture (USDA), Ames, Iowa, United States of America

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  • Nora Zidane,

    Affiliation: Plate-forme Génomique, Institut Pasteur, Paris, France

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  • Peter J. Wilson,

    Affiliation: Australian Genome Research Facility, Gehrmann Laboratories, University of Queensland, St. Lucia, Queensland, Australia

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  • Sophie Creno,

    Affiliation: Plate-forme Génomique, Institut Pasteur, Paris, France

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  • Elizabeth S. Kuczek,

    Affiliation: Australian Genome Research Facility, Gehrmann Laboratories, University of Queensland, St. Lucia, Queensland, Australia

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  • Simona Bommezzadri,

    Affiliation: Unité de Biologie des Spirochètes, Institut Pasteur, Paris, France

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  • John C. Davis,

    Affiliation: Australian Genome Research Facility, Gehrmann Laboratories, University of Queensland, St. Lucia, Queensland, Australia

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  • Annette McGrath,

    Affiliation: Australian Genome Research Facility, Gehrmann Laboratories, University of Queensland, St. Lucia, Queensland, Australia

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  • Matthew J. Johnson,

    Affiliation: Australian Genome Research Facility, Gehrmann Laboratories, University of Queensland, St. Lucia, Queensland, Australia

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  • Caroline Boursaux-Eude,

    Affiliation: Plate-forme Intégration et Analyse génomique, Institut Pasteur, Paris, France

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  • Torsten Seemann,

    Affiliation: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia

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  • Zoé Rouy,

    Affiliation: Commissariat à l'Energie Atomique (CEA), Direction des Sciences du Vivant, Laboratoire de Génomique Comparative, Institut de Génomique, Genoscope, Evry, France

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  • Ross L. Coppel,

    Affiliations: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia, Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Julian I. Rood,

    Affiliations: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia, Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton, Victoria, Australia, Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Aurélie Lajus,

    Affiliation: Commissariat à l'Energie Atomique (CEA), Direction des Sciences du Vivant, Laboratoire de Génomique Comparative, Institut de Génomique, Genoscope, Evry, France

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  • John K. Davies,

    Affiliations: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia, Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton, Victoria, Australia, Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Claudine Médigue,

    Affiliations: Commissariat à l'Energie Atomique (CEA), Direction des Sciences du Vivant, Laboratoire de Génomique Comparative, Institut de Génomique, Genoscope, Evry, France, Centre National de la Recherche Scientifique (CNRS) UMR8030, Génomique Métabolique, Evry, France

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  • Ben Adler mail

    *E-mail: Ben.Adler@med.monash.edu.au

    Affiliations: Victorian Bioinformatics Consortium, Monash University, Clayton, Victoria, Australia, Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton, Victoria, Australia, Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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  • Published: February 13, 2008
  • DOI: 10.1371/journal.pone.0001607
  • Published in PLOS ONE

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