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Research Article

Bimodal and Hysteretic Expression in Mammalian Cells from a Synthetic Gene Circuit

  • Tobias May,

    Affiliation: Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Braunschweig, Germany

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  • Lee Eccleston,

    Affiliation: Department of Engineering, University of Cambridge, Cambridge, United Kingdom

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  • Sabrina Herrmann,

    Affiliation: Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Braunschweig, Germany

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  • Hansjörg Hauser,

    Affiliation: Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Braunschweig, Germany

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  • Jorge Goncalves,

    Affiliation: Department of Engineering, University of Cambridge, Cambridge, United Kingdom

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  • Dagmar Wirth mail

    dagmar.wirth@helmholtz-hzi.de

    Affiliation: Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Braunschweig, Germany

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  • Published: June 04, 2008
  • DOI: 10.1371/journal.pone.0002372
  • Published in PLOS ONE

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