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Research Article

High-Level Production of Amorpha-4,11-Diene, a Precursor of the Antimalarial Agent Artemisinin, in Escherichia coli

  • Hiroko Tsuruta,

    Affiliation: Amyris Biotechnologies, Emeryville, California, United States of America

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  • Christopher J. Paddon mail,

    Paddon@amyris.com

    Affiliation: Amyris Biotechnologies, Emeryville, California, United States of America

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  • Diana Eng,

    Affiliation: Amyris Biotechnologies, Emeryville, California, United States of America

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  • Jacob R. Lenihan,

    Affiliation: Amyris Biotechnologies, Emeryville, California, United States of America

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  • Tizita Horning,

    Affiliation: Amyris Biotechnologies, Emeryville, California, United States of America

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  • Larry C. Anthony,

    Affiliation: Amyris Biotechnologies, Emeryville, California, United States of America

    Current address: DuPont Central Research & Development, Experimental Station E328/345B, Wilmington, Delaware, United States of America

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  • Rika Regentin,

    Affiliation: Amyris Biotechnologies, Emeryville, California, United States of America

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  • Jay D. Keasling,

    Affiliations: Departments of Chemical Engineering and of Bioengineering, University of California, Berkeley, California, United States of America, Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America, Joint BioEnergy Institute, Emeryville, California, United States of America

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  • Neil S. Renninger,

    Affiliation: Amyris Biotechnologies, Emeryville, California, United States of America

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  • Jack D. Newman

    Affiliation: Amyris Biotechnologies, Emeryville, California, United States of America

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  • Published: February 16, 2009
  • DOI: 10.1371/journal.pone.0004489
  • Published in PLOS ONE

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