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Research Article

Rational Design of Temperature-Sensitive Alleles Using Computational Structure Prediction

  • Christopher S. Poultney,

    Affiliation: Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America

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  • Glenn L. Butterfoss,

    Affiliation: Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America

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  • Michelle R. Gutwein,

    Affiliation: Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America

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  • Kevin Drew,

    Affiliation: Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America

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  • David Gresham,

    Affiliation: Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America

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  • Kristin C. Gunsalus,

    Affiliation: Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America

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  • Dennis E. Shasha,

    Affiliations: Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America, Computer Science Department, Courant Institute of Mathematical Sciences, New York University, New York, New York, United States of America

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  • Richard Bonneau mail

    bonneau@nyu.edu

    Affiliations: Department of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America, Computer Science Department, Courant Institute of Mathematical Sciences, New York University, New York, New York, United States of America

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  • Published: September 02, 2011
  • DOI: 10.1371/journal.pone.0023947
  • Published in PLOS ONE

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